Białecka Agnieszka, Białecki Marcin, Serafin Zbigniew, Czajkowski Rafał
Department of Dermatology and Venerology, Faculty of Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Department of Radiology and Diagnostic Imaging, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Postepy Dermatol Alergol. 2021 Aug;38(4):673-681. doi: 10.5114/ada.2021.108908. Epub 2021 Sep 17.
In recent years numerous research studies have indicated that chronic inflammation in psoriasis can be associated with an increased risk of developing atherosclerosis.
The presented study was aimed at demonstrating whether patients suffering from psoriasis vulgaris are at a greater risk of developing atherosclerosis depending on the presence of selected cardiovascular risk factors and the course and severity of the disease.
Sixty-two patients with diagnosed psoriasis vulgaris and 42 healthy volunteers were included in the study. All the patients underwent carotid ultrasound with the assessment of the common carotid artery intima-media thickness (IMT) and the computed tomography with determination of coronary artery calcification (CAC).
The IMT was significantly higher in the study group (1.030 ±0.303 mm vs. 0.838 ±0.151 mm, < 0.0001). We also found a significantly increased severity of Calcium Score (CS) in Agatston units (168.20 ±309.63 vs. 24.52 ±43.21, = 0.0207) of CAC in patients with psoriasis. There was no significant correlation between the degree of atherosclerosis and psoriasis severity determined in the PASI (Psoriasis Area and Severity Index) scale, duration of the disease, number of exacerbations per year or C-reactive protein values.
The study showed an increased risk of developing atherosclerosis in patients diagnosed with psoriasis vulgaris, but no correlation was found between the degree of atherosclerosis and the severity of the disease.
近年来，大量研究表明，银屑病中的慢性炎症可能与动脉粥样硬化风险增加有关。
本研究旨在证明寻常型银屑病患者是否因存在特定心血管危险因素以及疾病的病程和严重程度而具有更高的动脉粥样硬化风险。
本研究纳入了62例确诊为寻常型银屑病的患者和42名健康志愿者。所有患者均接受了颈动脉超声检查以评估颈总动脉内膜中层厚度（IMT），并进行了计算机断层扫描以测定冠状动脉钙化（CAC）。
研究组的IMT显著更高（1.030±0.303毫米对0.838±0.151毫米，<0.0001）。我们还发现，银屑病患者的CAC的阿加斯顿单位钙评分（CS）严重程度显著增加（168.20±309.63对24.52±43.21，=0.0207）。动脉粥样硬化程度与根据银屑病面积和严重程度指数（PASI）量表确定的银屑病严重程度、疾病持续时间、每年发作次数或C反应蛋白值之间无显著相关性。
该研究表明，确诊为寻常型银屑病的患者发生动脉粥样硬化的风险增加，但未发现动脉粥样硬化程度与疾病严重程度之间存在相关性。
