Radiology Department, Vanderbilt University, Institute of Imaging Science, Nashville, TN 37232, USA. :
Magn Reson Imaging. 2013 Apr;31(3):376-84. doi: 10.1016/j.mri.2012.11.011. Epub 2013 Jan 22.
Magnetic resonance imaging (MRI) protocols that are designed to be sensitive to iron typically take advantage of (1) iron effects on the relaxation of water protons and/or (2) iron-induced local magnetic field susceptibility changes. Increasing evidence sustains the notion that imaging iron in brain of patients with multiple sclerosis (MS) may add some specificity toward the identification of the disease pathology. The present review summarizes currently reported in vivo and post mortem MRI evidence of (1) iron detection in white matter and gray matter of MS brains, (2) pathological and physiological correlates of iron as disclosed by imaging and (3) relations between iron accumulation and disease progression as measured by clinical metrics.
磁共振成像（MRI）方案旨在对铁敏感，通常利用（1）铁对水质子弛豫的影响和/或（2）铁诱导的局部磁场磁化率变化。越来越多的证据支持这样一种观点，即在多发性硬化症（MS）患者的大脑中成像铁可能会增加对疾病病理学的识别特异性。本综述总结了目前报道的多发性硬化症脑（1）白质和灰质中铁的检测，（2）成像显示的铁的病理和生理相关性，以及（3）通过临床指标测量的铁积累与疾病进展之间的关系。
