Meng F, Chen Y, Ge S
Burn Center, Changhai Hospital, Second Military Medical University of PLA, Shanghai.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1994 Mar;10(2):134-7.
The anion transport property is the one of the most important functions of the erythrocyte. In this paper a new method is used to measure the NO2- and Cl- ions transport across the erythrocyte membrane in burned rats. It was found that the NO2- and Cl- transport rate across erythrocyte membrane became slower during shock stage in burned rats, being contrary to the results found in heat-treated erythrocytes in vitro. By using a specific inhibitor of anion transport, DIDS, it was shown that the abnormality of NO2- transport across the erythrocyte membrane in burned rats is due probably to a damage of extracellular domain of band 3 protein. The authors consider that the influence of membranotoxic factors and the disturbance of energy metabolism during burn shock stage are accounted for all the noticed alterations.
阴离子转运特性是红细胞最重要的功能之一。本文采用一种新方法来测量烧伤大鼠红细胞膜上NO2-和Cl-离子的转运。结果发现，烧伤大鼠休克期红细胞膜上NO2-和Cl-的转运速率变慢，这与体外热处理红细胞的结果相反。通过使用阴离子转运的特异性抑制剂二异丙基氟磷酸（DIDS），结果表明烧伤大鼠红细胞膜上NO2-转运异常可能是由于带3蛋白细胞外区域受损所致。作者认为，烧伤休克期膜毒性因子的影响和能量代谢紊乱是所有观察到的变化的原因。
