Department of Psychology, University of Utah, 380 South 1530 East, Rm 502, Salt Lake City, UT 84112-0251, USA.
Behav Brain Res. 2013 Oct 1;254:1-7. doi: 10.1016/j.bbr.2013.01.012. Epub 2013 Jan 21.
In this review article the emphasis will be on the role of the DG (dorsal and ventral) in supporting memory based on the operation of specific processes. Based on the development of computational models of dorsal dentate gyrus (dDG) and behavioral evidence based on dysfunction of dDG, this review will show that the dDG mediates mnemonic processing of spatial information. The processes subserved by dDG include (a) the operation of conjunctive encoding of multiple sensory inputs, implying an integration of sensory inputs to determine a spatial representation, and (b) pattern separation of spatial (especially metric) information, involving the reduction of interference between similar spatial locations (c) pattern separation of context (d) importance of context in object recognition, and (e) temporal integration and remote memory and spatial pattern separation based in part on neurogenesis. In addition the ventral dentate gyrus (vDG) mediates mnemonic processing of odor information as indicated by odor pattern separation.
在这篇综述文章中，重点将放在 DG（背侧和腹侧）在支持基于特定过程运作的记忆方面的作用。基于背侧齿状回（dDG）的计算模型的发展和基于 dDG 功能障碍的行为证据，本综述将表明 dDG 介导空间信息的记忆处理。dDG 支持的过程包括：（a）多种感觉输入的联合编码操作，这意味着整合感觉输入以确定空间表示，以及（b）空间（特别是度量）信息的模式分离，涉及到减少相似空间位置之间的干扰（c）上下文的模式分离（d）上下文在物体识别中的重要性，以及（e）时间整合和远程记忆以及基于部分神经发生的空间模式分离。此外，腹侧齿状回（vDG）介导气味信息的记忆处理，如气味模式分离所示。
