Kesner Raymond P, Hui Xu, Sommer Taylor, Wright Casey, Barrera Vanessa R, Fanselow Michael S
Department of Psychology, University of Utah, Salt Lake City, Utah.
Hippocampus. 2014 Dec;24(12):1663-71. doi: 10.1002/hipo.22346. Epub 2014 Aug 27.
In this study, we determined the contribution of juvenile neurogenesis to the performance of mice on a remote memory for temporally based association task and in a novelty based spatial pattern separation task. This was accomplished by mating homozygous DNMT1-loxP mice with heterozygous GFAP-Cre mice and comparing Cre+ (no postnatal neurogenesis) to Cre- (wild type) littermate offspring. The results indicate that Cre+ mice are impaired relative to Cre- mice in the remote memory for a temporal based association task and in a novelty based spatial pattern separation task. These results support the temporal integration model of Aimone et al., [(2006) Nat Neurosci 9:723-727] and provide further support for an important role for postnatally born neurons in spatial pattern separation. In contrast, Cre+ mice are not impaired relative to Cre- mice in an object-context recognition task and a spatial location recognition task. These latter data suggest that postnatally derived neurons in the dentate gyrus (DG) do not support all spatial and object recognition functions of the DG.
在本研究中，我们确定了幼年神经发生对小鼠在基于时间关联任务的远程记忆和基于新奇性的空间模式分离任务中的表现所起的作用。这是通过将纯合DNMT1-loxP小鼠与杂合GFAP-Cre小鼠交配，并将Cre+（无出生后神经发生）与Cre-（野生型）同窝仔代进行比较来实现的。结果表明，在基于时间关联任务的远程记忆和基于新奇性的空间模式分离任务中，Cre+小鼠相对于Cre-小鼠存在缺陷。这些结果支持了Aimone等人（2006年，《自然神经科学》9:723 - 727）的时间整合模型，并为出生后产生的神经元在空间模式分离中的重要作用提供了进一步支持。相比之下，在物体-情境识别任务和空间位置识别任务中，Cre+小鼠相对于Cre-小鼠并未受损。这些后期数据表明，齿状回（DG）中出生后产生的神经元并不支持DG的所有空间和物体识别功能。
