Kesner Raymond P, Taylor James O, Hoge Jennifer, Andy Ford
University of Utah, Department of Psychology, USA.
Neurobiol Learn Mem. 2015 Feb;118:42-8. doi: 10.1016/j.nlm.2014.11.004. Epub 2014 Nov 12.
In the present study the effects of dorsal dentate gyrus (dDG) lesions in rats were tested on recognition memory tasks based on the interaction between objects, features of objects, and spatial features. The results indicated that the rats with dDG lesions did not differ from controls in recognition for a change within object feature configuration and object recognition tasks. In contrast, there was a deficit for the dDG lesioned rats relative to controls in recognition for a change within object-spatial feature configuration, complex object-place feature configuration and spatial recognition tasks. It is suggested that the dDG subregion of the hippocampus supports object-place and complex object-place feature information via a conjunctive encoding process.
在本研究中，基于物体之间的相互作用、物体特征和空间特征，测试了大鼠背侧齿状回（dDG）损伤对识别记忆任务的影响。结果表明，在物体特征配置变化和物体识别任务的识别方面，dDG损伤的大鼠与对照组没有差异。相比之下，在物体-空间特征配置变化、复杂物体-位置特征配置和空间识别任务的识别方面，dDG损伤的大鼠相对于对照组存在缺陷。这表明海马体的dDG亚区域通过联合编码过程支持物体-位置和复杂物体-位置特征信息。
