Bhattacharyya S, Mukhopadhyay M, Bhattacharyya I, Lahiri S K, Mitra P K, Dutta U K
Department of Biochemistry, RG Kar Medical College, Kolkata.
J Indian Med Assoc. 2007 Jul;105(7):370, 372, 374 passim.
Increasing prevalence of diabetes mellitus (DM), hypertension (HT), coronary heart disease (CHD) is alarming; risk factors are fairly stable, passing fairly well from childhood to adulthood; genetic factors play a role. This is important to know the status of some biochemical parameters viz, fasting plasma glucose level, fasting serum insulin (FI), serum triglyceride (STG), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) among the medicos with family history (FH) of DM, HT or CHD and the relationship of biochemical parameters with body mass index (BMI). Mean age of the sample (n=67) was 22 years with 76.12% males and 23.88% females; 44.78%, 29.85% and 19.40% had FH of DM, HT and CHD respectively; 8.96% had the FH of three diseases. High BMI was seen in 62.69% cases; it was significantly high among those with FH of DM (p<0.05) but not significant against HT (p>0.05) or CHD (p>0.05). All had normal fasting plasma glucose level. Positive association existed (a) between BMI with FI, LDL and HDL, FI with LDL and HDL, TG with TC, TC with LDL and HDL, LDL with HDL among those with FH of DM; (b) between BMI with FI, STG and HDL, FI with LDL and HDL, TC with LDL and HDL, LDL with HDL among those with FH of HT; (c) between BMI with FI, STG and HDL, FI with TC, LDL and HDL, TC with LDL and HDL, LDL with HDL among those with FH of CHD. Multiple correlation coefficients (R) also indicated moderate association.
糖尿病（DM）、高血压（HT）、冠心病（CHD）患病率的不断上升令人担忧；危险因素相当稳定，从儿童期到成年期变化不大；遗传因素也起作用。了解一些生化参数的状况很重要，即有DM、HT或CHD家族史（FH）的医务人员的空腹血糖水平、空腹血清胰岛素（FI）、血清甘油三酯（STG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL），以及生化参数与体重指数（BMI）的关系。样本（n = 67）的平均年龄为22岁，男性占76.12%，女性占23.88%；分别有44.78%、29.85%和19.40%的人有DM、HT和CHD的家族史；8.96%的人有三种疾病的家族史。62.69%的病例BMI较高；DM家族史者的BMI显著较高（p < 0.05），但与HT家族史者（p > 0.05）或CHD家族史者（p > 0.05）相比无显著差异。所有人的空腹血糖水平均正常。在有DM家族史的人群中，（a）BMI与FI、LDL和HDL之间，FI与LDL和HDL之间，TG与TC之间，TC与LDL和HDL之间，LDL与HDL之间存在正相关；在有HT家族史的人群中，（b）BMI与FI、STG和HDL之间，FI与LDL和HDL之间，TC与LDL和HDL之间，LDL与HDL之间存在正相关；在有CHD家族史的人群中，（c）BMI与FI、STG和HDL之间，FI与TC、LDL和HDL之间，TC与LDL和HDL之间，LDL与HDL之间存在正相关。复相关系数（R）也表明存在中度相关性。
