CNR-ISTEC, National Research Council, Institute of Science and Technology for Ceramics, via Granarolo 64, 48018 Faenza, Italy.
J Biomed Mater Res A. 2013 Sep;101(9):2481-90. doi: 10.1002/jbm.a.34553. Epub 2013 Jan 24.
Porous macro-granules of nanostructured apatite with Ca ions partially cosubstituted with Mg and Sr ions in different ratios (SrMgHAs), were synthesized at 37°C and compared with Mg and/or Sr free apatites (MgHAs and HA). Strontium improved the Mg substitution extent in the apatite and the chemical-physical and thermal stability of the resulting cosubstituted apatite. Porous macro-granules of 400-600 micron with selected composition were tested for the ionic release in synthetic body fluid and the data were related with the results of preliminary cell investigation in vitro. As compared to the corresponding Sr-free granulate, the SrMgHA could be exploited to prolong the beneficial Mg release during the bone regeneration process. In addition the contemporary in situ supply of Sr, an antiosteoporotic and anticarie ion, could influence the quality of new hard tissues. The ionic multirelease created a more favorable environment for human osteoblasts, demonstrated by a proliferative effect for each dose tested in the range 0.1-10 mg/mL.
具有纳米结构的磷灰石的多孔大颗粒，其中 Ca 离子部分被 Mg 和 Sr 离子以不同比例共取代（SrMgHAs），在 37°C 下合成，并与不含 Mg 和/或 Sr 的磷灰石（MgHAs 和 HA）进行了比较。 Sr 提高了磷灰石中 Mg 的取代程度以及所得共取代磷灰石的物理化学和热稳定性。选择组成的 400-600 微米的多孔大颗粒在合成体液中进行了离子释放测试，并将数据与体外初步细胞研究的结果相关联。与相应的无 Sr 颗粒相比，SrMgHA 可用于延长骨再生过程中有益的 Mg 释放。此外，Sr 的即时原位供应，一种抗骨质疏松和抗龋齿离子，可能会影响新硬组织的质量。离子的多重释放为人类成骨细胞创造了更有利的环境，通过在 0.1-10mg/mL 的测试范围内，每种剂量的增殖作用证明了这一点。
