锶掺入磷酸钙是否能改善骨修复？一项荟萃分析。

Does the incorporation of strontium into calcium phosphate improve bone repair? A meta-analysis.

机构信息

Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Department of Oral Implantology, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou, 350002, China.

出版信息

BMC Oral Health. 2022 Mar 8;22(1):62. doi: 10.1186/s12903-022-02092-7.

BACKGROUND

The application of calcium phosphate (CaP)-based bone substitutes plays an important role in periodontal regeneration, implant dentistry and alveolar bone reconstruction. The incorporation of strontium (Sr) into CaP-based bone substitutes appears to improve their biological properties, but the reported in vivo bone repair performance is inconsistent among studies. Herein, we conducted a systematic review and meta-analysis to investigate the in vivo performance of Sr-doped materials.

METHODS

We searched PubMed, EMBASE (via OVIDSP), and reference lists to identify relevant animal studies. The search, study selection, and data extraction were performed independently by two investigators. Meta-analyses and sub-group analyses were conducted using Revman version 5.4.1. The heterogeneity between studies were assessed by I. Publication bias was investigated through a funnel plot.

RESULTS

Thirty-five studies were finally enrolled, of which 16 articles that reported on new bone formation (NBF) were included in the meta-analysis, covering 31 comparisons and 445 defects. The overall effect for NBF was 2.25 (95% CI 1.61-2.90, p < 0.00001, I = 80%). Eight comparisons from 6 studies reported the outcomes of bone volume/tissue volume (BV/TV), with an overall effect of 1.42 (95% CI 0.65-2.18, p = 0.0003, I = 75%). Fourteen comparisons reported on the material remaining (RM), with the overall effect being -2.26 (95% CI - 4.02 to - 0.50, p = 0.0009, I = 86%).

CONCLUSIONS

Our study revealed that Sr-doped calcium phosphate bone substitutes improved in vivo performance of bone repair. However, more studies are also recommended to further verify this conclusion.

背景

磷酸钙（CaP）基骨替代物的应用在牙周再生、种植体牙科和牙槽骨重建中起着重要作用。锶（Sr）掺入 CaP 基骨替代物似乎可以改善其生物性能，但不同研究报道的体内骨修复性能不一致。在此，我们进行了系统评价和荟萃分析，以研究 Sr 掺杂材料的体内性能。

方法

我们检索了 PubMed、EMBASE（通过 OVIDSP）和参考文献列表，以确定相关的动物研究。搜索、研究选择和数据提取由两名研究人员独立进行。使用 Revman 版本 5.4.1 进行荟萃分析和亚组分析。通过 I 评估研究之间的异质性。通过漏斗图研究发表偏倚。

结果

最终纳入 35 项研究，其中 16 项报道新骨形成（NBF）的文章纳入荟萃分析，涵盖 31 项比较和 445 个缺陷。NBF 的总体效果为 2.25（95%CI 1.61-2.90，p<0.00001，I=80%）。来自 6 项研究的 8 项比较报告了骨体积/组织体积（BV/TV）的结果，总体效果为 1.42（95%CI 0.65-2.18，p=0.0003，I=75%）。14 项比较报告了材料残留（RM），总体效果为-2.26（95%CI-4.02 至-0.50，p=0.0009，I=86%）。