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一种用于阴道柱状体治疗计划的新方法:向三维近距离放射治疗的无缝过渡。

A novel method for vaginal cylinder treatment planning: a seamless transition to 3D brachytherapy.

作者信息

Malhotra Harish K, Wu Vincent, Wang Zhou, Patil Sachin

机构信息

Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, USA.

出版信息

J Contemp Brachytherapy. 2012 Jun;4(2):92-100. doi: 10.5114/jcb.2012.29365. Epub 2012 Jun 30.

Abstract

PURPOSE

Standard treatment plan libraries are often used to ensure a quick turn-around time for vaginal cylinder treatments. Recently there is increasing interest in transitioning from conventional 2D radiograph based brachytherapy to 3D image based brachytherapy, which has resulted in a substantial increase in treatment planning time and decrease in patient through-put. We describe a novel technique that significantly reduces the treatment planning time for CT-based vaginal cylinder brachytherapy.

MATERIAL AND METHODS

Oncentra MasterPlan TPS allows multiple sets of data points to be classified as applicator points which has been harnessed in this method. The method relies on two hard anchor points: the first dwell position in a catheter and an applicator configuration specific dwell position as the plan origin and a soft anchor point beyond the last active dwell position to define the axis of the catheter. The spatial location of various data points on the applicator's surface and at 5 mm depth are stored in an Excel file that can easily be transferred into a patient CT data set using window operations and then used for treatment planning. The remainder of the treatment planning process remains unaffected.

RESULTS

The treatment plans generated on the Oncentra MasterPlan TPS using this novel method yielded results comparable to those generated on the Plato TPS using a standard treatment plan library in terms of treatment times, dwell weights and dwell times for a given optimization method and normalization points. Less than 2% difference was noticed between the treatment times generated between both systems. Using the above method, the entire planning process, including CT importing, catheter reconstruction, multiple data point definition, optimization and dose prescription, can be completed in ~5-10 minutes.

CONCLUSION

The proposed method allows a smooth and efficient transition to 3D CT based vaginal cylinder brachytherapy planning.

摘要

目的

标准治疗计划库常用于确保阴道施源器治疗能快速周转。近来,从传统基于二维X线片的近距离放射治疗向基于三维图像的近距离放射治疗转变的兴趣日益浓厚,这导致治疗计划时间大幅增加,患者 throughput 下降。我们描述了一种新技术,可显著减少基于CT的阴道施源器近距离放射治疗的治疗计划时间。

材料与方法

Oncentra MasterPlan TPS允许将多组数据点分类为施源器点,本方法利用了这一点。该方法依赖于两个硬锚点:导管中的第一个驻留位置和特定施源器配置的驻留位置作为计划原点,以及超出最后一个有效驻留位置的软锚点来定义导管轴。施源器表面及5毫米深度处各种数据点的空间位置存储在Excel文件中,可通过窗口操作轻松转移到患者CT数据集中,然后用于治疗计划。治疗计划过程的其余部分不受影响。

结果

对于给定的优化方法和归一化点,使用这种新方法在Oncentra MasterPlan TPS上生成的治疗计划在治疗时间、驻留权重和驻留时间方面产生的结果与使用标准治疗计划库在Plato TPS上生成的结果相当。两个系统生成的治疗时间之间的差异不到2%。使用上述方法,整个计划过程,包括CT导入、导管重建、多个数据点定义、优化和剂量处方,可在约5 - 10分钟内完成。

结论

所提出的方法允许顺利、高效地过渡到基于三维CT的阴道施源器近距离放射治疗计划。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3f2/3552630/a4727d6b990e/JCB-4-18874-g001.jpg

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