女性生殖道胚胎性横纹肌肉瘤：5年经验
Embryonal rhabdomyosarcoma of the female genital tract: 5 years' experience.
作者信息
Hemida Reda, Goda Hosam, Abdel-Hady El-Said, El-Ashry Rasha
机构信息
Department of Obstetrics and Gynecology, Mansoura University, Egypt.
出版信息
J Exp Ther Oncol. 2012;10(2):135-7.
OBJECTIVES
To present our single institution experience with 10 cases of embryonal rhabdomyosarcoma diagnosed over 5 years.
METHODS
Retrospective analysis of the medical records of 10 patients. The initial presenting data as age, complains and staging were analyzed. Surgical interference of all cases was studied. The follow up data regarding survival and recurrences were analyzed.
RESULTS
The mean age at diagnosis was 4.3 years (range: 2-12). Six cases (60%) were subjected to "True Cut" biopsy and 4 cases (40%) were subjected to complete surgical excision of the tumor. All cases received chemotherapy. "Vincristine, Actinomycin D, Cyclophosphamide" combination was the most commonly used. Radiation therapy was used in 3 patients (30%) in the form of external beam radiation. The 5-year overall survival of our studied cases were 80%.
CONCLUSION
The recurrence rate of our retrospectively studied 10 cases of embryonal rhabdomyosarcoma of vagina and cervix was high (70%). However, five-year survival was 80%. Combined modality treatment is essential to improve prognosis.
目的
介绍我们单机构在5年期间诊断出的10例胚胎性横纹肌肉瘤的经验。
方法
对10例患者的病历进行回顾性分析。分析初始呈现的数据，如年龄、主诉和分期。研究所有病例的手术干预情况。分析关于生存和复发的随访数据。
结果
诊断时的平均年龄为4.3岁（范围：2 - 12岁）。6例（60%）接受了“True Cut”活检，4例（40%）接受了肿瘤的完整手术切除。所有病例均接受化疗。“长春新碱、放线菌素D、环磷酰胺”联合方案是最常用的。3例患者（30%）接受了外照射形式的放射治疗。我们研究病例的5年总生存率为80%。
结论
我们回顾性研究的10例阴道和宫颈胚胎性横纹肌肉瘤的复发率较高（70%）。然而，5年生存率为80%。综合治疗对于改善预后至关重要。
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