Tsung Ann H, Williams Justin B, Whitford Allen C
Department of Surgery, Division of Emergency Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
J Emerg Med. 2013 May;44(5):939-42. doi: 10.1016/j.jemermed.2012.11.009. Epub 2013 Jan 23.
Pulmonary embolism (PE) is a life-threatening condition that is extremely uncommon in the healthy pediatric population.
Because pediatric PE is rarely on the Emergency Physician's differential diagnosis, with this case we hope to increase the clinical suspicion for PE in children who present to the Emergency Department (ED).
This is a case of bilateral pulmonary embolism in a 16-year-old basketball player whose only risk factor is oral contraceptive medication. Initial vital signs demonstrated a temperature of 37.1°C (98.8°F), blood pressure 124/74 mm Hg, heart rate 74 beats/min, respiratory rate 16 breaths/min, and oxygen saturation 100% on room air. Subsequent vital signs, physical examination, chest radiograph, electrocardiogram, and laboratory assessments were all within normal limits. Using clinician gestalt in combination with the patient's Wells score of 0, a D-dimer was obtained and returned at 1916 ng/mL. The computed tomography scan with PE protocol detected a total of seven pulmonary emboli bilaterally. The patient was anticoagulated with Lovenox (Sanofi US, Bridgewater, NJ) in the ED and admitted to the pediatric intensive care unit. Complete thrombophilia work-up was negative. The patient was discharged with Lovenox and was transitioned to warfarin.
Emergency Physicians may be inclined to discharge a pediatric patient at low pre-test probability for PE with outpatient follow-up if the work-up is non-contributory. But the current adult PE clinical criteria are not as sensitive or specific in the pediatric population. This case demonstrates that the clinician's gestalt should play a major role in combination with the Wells score and PERC (pulmonary embolism rule-out criteria) rule to exclude PE until clinical decision rules specific for the pediatric population are established.
肺栓塞(PE)是一种危及生命的疾病,在健康的儿科人群中极为罕见。
由于儿科PE很少出现在急诊医生的鉴别诊断中,通过本病例我们希望提高对就诊于急诊科(ED)的儿童PE的临床怀疑度。
这是一例16岁篮球运动员双侧肺栓塞的病例,其唯一的危险因素是口服避孕药。初始生命体征显示体温37.1°C(98.8°F),血压124/74 mmHg,心率74次/分钟,呼吸频率16次/分钟,室内空气中氧饱和度100%。随后的生命体征、体格检查、胸部X光片、心电图和实验室检查均在正常范围内。结合临床直觉以及患者Wells评分为0,检测了D-二聚体,结果为1916 ng/mL。采用PE方案的计算机断层扫描共检测到双侧七个肺栓塞。患者在急诊科接受了依诺肝素(赛诺菲美国公司,新泽西州布里奇沃特)抗凝治疗,并入住儿科重症监护病房。全面的血栓形成倾向检查结果为阴性。患者出院时带依诺肝素,并过渡到华法林治疗。
如果检查无异常,急诊医生可能倾向于让PE预测试概率低的儿科患者进行门诊随访后出院。但目前成人PE临床标准在儿科人群中不够敏感或特异。本病例表明,在建立针对儿科人群的临床决策规则之前,临床直觉应与Wells评分和PERC(肺栓塞排除标准)规则相结合,在排除PE方面发挥主要作用。