Iwabu Masato, Yamauchi Toshimasa, Okada-Iwabu Miki, Kadowaki Takashi
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan.
Clin Calcium. 2016 Mar;26(3):413-8.
Given that appropriate control of responses of the body to nutritional status is assumed to modulate the pace of aging, thus prolonging lifespan and maintaining youth in humans, expectations are mounting worldwide for modalities targeting the pathways in metabolic regulation for healthy longevity. Of these, this review focuses attention on adiponectin-targeted therapy and discusses milestones in this approach, which include the discovery of the ability of adiponectin to protect against lifestyle-related diseases, identification of its receptors (AdipoRs), elucidation of AdipoR-mediated signaling pathways that promote healthy longevity and acquisition of small-molecule AdipoR agonist, and explores future prospects on adiponectin-targeted therapy.
鉴于身体对营养状况的反应得到适当控制被认为可以调节衰老速度，从而延长人类寿命并保持年轻，全球对针对代谢调节途径以实现健康长寿的方法的期望越来越高。其中，本综述重点关注靶向脂联素的疗法，并讨论该方法中的重要进展，包括发现脂联素预防生活方式相关疾病的能力、鉴定其受体（脂联素受体）、阐明促进健康长寿的脂联素受体介导的信号通路以及获得小分子脂联素受体激动剂，并探讨靶向脂联素疗法的未来前景。
