mTOR，连接代谢与免疫。
mTOR, linking metabolism and immunity.
机构信息
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Semin Immunol. 2012 Dec;24(6):429-35. doi: 10.1016/j.smim.2012.12.005. Epub 2013 Jan 24.
Abstract
mTOR is an evolutionarily conserved serine/threonine kinase that plays a critical role in cell growth and metabolism by sensing different environmental cues. There is a growing appreciation of mTOR in immunology for its role in integrating diverse signals from the immune microenvironment and coordinating the functions of immune cells and their metabolism. In CD8 T cells, mTOR has shown to influence cellular commitment to effector versus memory programming; in CD4 T cells, mTOR integrates environmental cues that instruct effector cell differentiation. In this review, we summarize and discuss recent advances in the field, with a focus on the mechanisms through which mTOR regulates cellular and humoral immunity. Further understanding will enable the manipulation of mTOR signaling to direct the biological functions of immune cells, which holds great potential for improving immune therapies and vaccination against infections and cancer.
摘要
mTOR 是一种进化上保守的丝氨酸/苏氨酸激酶，通过感知不同的环境线索，在细胞生长和代谢中发挥关键作用。mTOR 在免疫学中的作用越来越受到重视，因为它在整合免疫微环境中的各种信号以及协调免疫细胞及其代谢功能方面发挥着重要作用。在 CD8 T 细胞中，mTOR 已被证明影响细胞向效应器与记忆编程的定向；在 CD4 T 细胞中，mTOR 整合了指导效应细胞分化的环境线索。在这篇综述中，我们总结和讨论了该领域的最新进展，重点介绍了 mTOR 调节细胞和体液免疫的机制。进一步的理解将使我们能够操纵 mTOR 信号，从而指导免疫细胞的生物学功能，这对于改善免疫治疗和针对感染和癌症的疫苗接种具有巨大的潜力。
相似文献
1
mTOR, linking metabolism and immunity.mTOR，连接代谢与免疫。
Semin Immunol. 2012 Dec;24(6):429-35. doi: 10.1016/j.smim.2012.12.005. Epub 2013 Jan 24.
2
Regulation of immune responses by mTOR.mTOR 对免疫反应的调节。
Annu Rev Immunol. 2012;30:39-68. doi: 10.1146/annurev-immunol-020711-075024. Epub 2011 Nov 29.
3
mTOR regulates T-cell differentiation and activation in immunity and autoimmunity.哺乳动物雷帕霉素靶蛋白（mTOR）在免疫和自身免疫中调节T细胞分化和激活。
Crit Rev Eukaryot Gene Expr. 2011;21(4):313-22. doi: 10.1615/critreveukargeneexpr.v21.i4.20.
4
Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function.感知免疫微环境以协调 T 细胞代谢、分化和功能。
Semin Immunol. 2012 Dec;24(6):414-20. doi: 10.1016/j.smim.2012.12.003. Epub 2013 Jan 14.
5
Regulation and function of mTOR signalling in T cell fate decisions.mTOR 信号在 T 细胞命运决定中的调控和功能。
Nat Rev Immunol. 2012 Apr 20;12(5):325-38. doi: 10.1038/nri3198.
6
mTOR, metabolism, and the regulation of T-cell differentiation and function.mTOR、代谢与 T 细胞分化和功能的调控。
Immunol Rev. 2012 Sep;249(1):43-58. doi: 10.1111/j.1600-065X.2012.01152.x.
7
The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism.哺乳动物雷帕霉素靶蛋白：连接 T 细胞分化、功能和代谢。
Immunity. 2010 Sep 24;33(3):301-11. doi: 10.1016/j.immuni.2010.09.002.
8
mTOR signaling and transcriptional regulation in T lymphocytes.T淋巴细胞中的mTOR信号传导与转录调控
Transcription. 2014;5(2):e28263. doi: 10.4161/trns.28263.
9
mTOR and metabolic pathways in T cell quiescence and functional activation.mTOR 与 T 细胞静止和功能激活中的代谢途径。
Semin Immunol. 2012 Dec;24(6):421-8. doi: 10.1016/j.smim.2012.12.004. Epub 2013 Feb 1.
10
mTOR signalling and metabolic regulation of T cell differentiation.mTOR 信号通路与 T 细胞分化的代谢调控
Curr Opin Immunol. 2010 Oct;22(5):655-61. doi: 10.1016/j.coi.2010.08.010. Epub 2010 Sep 15.
引用本文的文献
1
Persistent immune dysregulation and metabolic alterations following SARS-CoV-2 infection.新型冠状病毒感染后持续存在的免疫失调和代谢改变。
medRxiv. 2025 Apr 17:2025.04.16.25325949. doi: 10.1101/2025.04.16.25325949.
2
Growth performance, nutrient utilization, gut integrity, short-chain fatty acids, and gene expression in Eimeria-challenged broilers receiving stimbiotics and wheat bran as an additional fiber source.接受合生元和麦麸作为额外纤维来源的艾美耳球虫攻击的肉鸡的生长性能、养分利用率、肠道完整性、短链脂肪酸和基因表达
Poult Sci. 2025 Apr;104(4):104877. doi: 10.1016/j.psj.2025.104877. Epub 2025 Feb 2.
3
Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism.毛兰素通过抑制mTOR激活和扰乱嘧啶代谢来抑制肺癌细胞的增殖。
Cancer Biol Med. 2025 Feb 24;22(2):144-65. doi: 10.20892/j.issn.2095-3941.2024.0385.
4
Deep learning analysis of histopathological images predicts immunotherapy prognosis and reveals tumour microenvironment features in non-small cell lung cancer.深度学习分析组织病理学图像预测非小细胞肺癌的免疫治疗预后并揭示肿瘤微环境特征。
Br J Cancer. 2024 Dec;131(11):1833-1845. doi: 10.1038/s41416-024-02856-8. Epub 2024 Oct 25.
5
Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis.雷帕霉素靶蛋白（mTOR）：类风湿关节炎潜在的新治疗靶点。
Arthritis Res Ther. 2023 Oct 2;25(1):187. doi: 10.1186/s13075-023-03181-w.
6
Autoimmune lymphoproliferative immunodeficiencies (ALPID) in childhood: breakdown of immune homeostasis and immune dysregulation.儿童自身免疫性淋巴增殖性免疫缺陷病（ALPID）：免疫稳态破坏与免疫失调
Mol Cell Pediatr. 2023 Sep 13;10(1):11. doi: 10.1186/s40348-023-00167-1.
7
Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapy.靶向mTOR作为癌症治疗方法：天然生物活性化合物与免疫疗法的最新进展
Cancers (Basel). 2022 Nov 10;14(22):5520. doi: 10.3390/cancers14225520.
8
Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration.mTOR信号通路在椎间盘退变中的新兴作用及治疗意义
Cell Prolif. 2023 Jan;56(1):e13338. doi: 10.1111/cpr.13338. Epub 2022 Oct 3.
9
White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp.白斑综合征病毒通过聚合免疫球蛋白受体介导的感染直接激活 mTORC1 信号通路，从而促进其在虾中的复制。
PLoS Pathog. 2022 Sep 6;18(9):e1010808. doi: 10.1371/journal.ppat.1010808. eCollection 2022 Sep.
10
mTOR pathway gene mutations predict response to immune checkpoint inhibitors in multiple cancers.mTOR 通路基因突变更预测多种癌症对免疫检查点抑制剂的反应。
J Transl Med. 2022 May 31;20(1):247. doi: 10.1186/s12967-022-03436-1.
本文引用的文献
1
mTOR, metabolism, and the regulation of T-cell differentiation and function.mTOR、代谢与 T 细胞分化和功能的调控。
Immunol Rev. 2012 Sep;249(1):43-58. doi: 10.1111/j.1600-065X.2012.01152.x.
2
Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation.miR-17-92 簇的时间表达调控效应器和记忆 CD8+T 细胞分化。
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9965-70. doi: 10.1073/pnas.1207327109. Epub 2012 Jun 4.
3
Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.衔接蛋白 Bcl10 的选择性自噬调节 T 细胞受体激活 NF-κB。
Immunity. 2012 Jun 29;36(6):947-58. doi: 10.1016/j.immuni.2012.04.008. Epub 2012 May 31.
4
Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells.哺乳动物雷帕霉素靶蛋白整合多种输入信息，指导 T 细胞对抗原的识别结果。
J Immunol. 2012 May 15;188(10):4721-9. doi: 10.4049/jimmunol.1103143.
5
Regulation and function of mTOR signalling in T cell fate decisions.mTOR 信号在 T 细胞命运决定中的调控和功能。
Nat Rev Immunol. 2012 Apr 20;12(5):325-38. doi: 10.1038/nri3198.
6
mTOR signaling in growth control and disease.mTOR 信号在生长控制和疾病中的作用。
Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
7
Regulatory T cells: mechanisms of differentiation and function.调节性 T 细胞：分化和功能的机制。
Annu Rev Immunol. 2012;30:531-64. doi: 10.1146/annurev.immunol.25.022106.141623. Epub 2012 Jan 6.
8
Germinal centers.生发中心。
Annu Rev Immunol. 2012;30:429-57. doi: 10.1146/annurev-immunol-020711-075032. Epub 2012 Jan 3.
9
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.转录因子 Myc 在 T 淋巴细胞激活时控制代谢重编程。
Immunity. 2011 Dec 23;35(6):871-82. doi: 10.1016/j.immuni.2011.09.021.
10
Regulation of immune responses by mTOR.mTOR 对免疫反应的调节。
Annu Rev Immunol. 2012;30:39-68. doi: 10.1146/annurev-immunol-020711-075024. Epub 2011 Nov 29.
Zotero 插件