Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Semin Immunol. 2012 Dec;24(6):429-35. doi: 10.1016/j.smim.2012.12.005. Epub 2013 Jan 24.
mTOR is an evolutionarily conserved serine/threonine kinase that plays a critical role in cell growth and metabolism by sensing different environmental cues. There is a growing appreciation of mTOR in immunology for its role in integrating diverse signals from the immune microenvironment and coordinating the functions of immune cells and their metabolism. In CD8 T cells, mTOR has shown to influence cellular commitment to effector versus memory programming; in CD4 T cells, mTOR integrates environmental cues that instruct effector cell differentiation. In this review, we summarize and discuss recent advances in the field, with a focus on the mechanisms through which mTOR regulates cellular and humoral immunity. Further understanding will enable the manipulation of mTOR signaling to direct the biological functions of immune cells, which holds great potential for improving immune therapies and vaccination against infections and cancer.
mTOR 是一种进化上保守的丝氨酸/苏氨酸激酶，通过感知不同的环境线索，在细胞生长和代谢中发挥关键作用。mTOR 在免疫学中的作用越来越受到重视，因为它在整合免疫微环境中的各种信号以及协调免疫细胞及其代谢功能方面发挥着重要作用。在 CD8 T 细胞中，mTOR 已被证明影响细胞向效应器与记忆编程的定向；在 CD4 T 细胞中，mTOR 整合了指导效应细胞分化的环境线索。在这篇综述中，我们总结和讨论了该领域的最新进展，重点介绍了 mTOR 调节细胞和体液免疫的机制。进一步的理解将使我们能够操纵 mTOR 信号，从而指导免疫细胞的生物学功能，这对于改善免疫治疗和针对感染和癌症的疫苗接种具有巨大的潜力。
Semin Immunol. 2013-1-24
Annu Rev Immunol. 2011-11-29
Crit Rev Eukaryot Gene Expr. 2011
Semin Immunol. 2013-1-14
Nat Rev Immunol. 2012-4-20
Immunol Rev. 2012-9
Transcription. 2014
Semin Immunol. 2013-2-1
Curr Opin Immunol. 2010-9-15
Arthritis Res Ther. 2023-10-2
Cancers (Basel). 2022-11-10
Immunol Rev. 2012-9
Proc Natl Acad Sci U S A. 2012-6-4
Nat Rev Immunol. 2012-4-20
Cell. 2012-4-13
Annu Rev Immunol. 2012-1-6
Annu Rev Immunol. 2012-1-3
Annu Rev Immunol. 2011-11-29
Zotero 插件