mTOR 对免疫反应的调节。
Regulation of immune responses by mTOR.
机构信息
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
出版信息
Annu Rev Immunol. 2012;30:39-68. doi: 10.1146/annurev-immunol-020711-075024. Epub 2011 Nov 29.
Abstract
mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in integrating environmental cues in the form of growth factors, amino acids, and energy. In the study of the immune system, mTOR is emerging as a critical regulator of immune function because of its role in sensing and integrating cues from the immune microenvironment. With the greater appreciation of cellular metabolism as an important regulator of immune cell function, mTOR is proving to be a vital link between immune function and metabolism. In this review, we discuss the ability of mTOR to direct the adaptive immune response. Specifically, we focus on the role of mTOR in promoting differentiation, activation, and function in T cells, B cells, and antigen-presenting cells.
摘要
mTOR 是一种进化上保守的丝氨酸/苏氨酸激酶，在整合生长因子、氨基酸和能量等形式的环境线索方面发挥着核心作用。在免疫系统研究中，mTOR 作为免疫功能的关键调节剂而崭露头角，因为它在感知和整合免疫微环境中的线索方面发挥着作用。随着人们越来越认识到细胞代谢是免疫细胞功能的重要调节剂，mTOR 被证明是免疫功能和代谢之间的重要联系。在这篇综述中，我们讨论了 mTOR 指导适应性免疫反应的能力。具体来说，我们专注于 mTOR 在促进 T 细胞、B 细胞和抗原呈递细胞的分化、激活和功能方面的作用。
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