他莫昔芬及其代谢产物的抗氧化作用。抑制脂质过氧化。
The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation.
作者信息
Wiseman H, Laughton M J, Arnstein H R, Cannon M, Halliwell B
机构信息
Department of Biochemistry, University of London, King's College, Strand Campus, UK.
出版信息
FEBS Lett. 1990 Apr 24;263(2):192-4. doi: 10.1016/0014-5793(90)81371-t.
PMID:2335223
Abstract
The anti-oestrogen drug tamoxifen is an inhibitor of lipid peroxidation in rat liver microsomes and in phospholipid liposomes. Its cis isomer and N-desmethyl form are weaker inhibitors, but 4-hydroxytamoxifen is much more powerful. It is possible that the antioxidant property of tamoxifen might contribute to its biological actions.
摘要
抗雌激素药物他莫昔芬是大鼠肝微粒体和磷脂脂质体中脂质过氧化的抑制剂。其顺式异构体和N-去甲基形式是较弱的抑制剂，但4-羟基他莫昔芬的作用更强。他莫昔芬的抗氧化特性可能有助于其生物学作用。
Zotero 插件