Hoffmann-La Roche Inc, pRED, Pharma Research & Early Development, DTA Inflammation, 340 Kingsland Street, Nutley 07110, United States.
Pulm Pharmacol Ther. 2013 Aug;26(4):459-63. doi: 10.1016/j.pupt.2013.01.004. Epub 2013 Jan 23.
Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality, which is most commonly associated with smoking or exposure to environmental pollutants. Unfortunately, there is an inadequate understanding of the molecular and physiological determinants governing one's susceptibility for developing COPD. Here, we describe a novel hypothesis: Individuals with intrinsically low aerobic exercise capacity are more likely to develop COPD after exposure to key risk factors. The hypothesis is based on observations that aerobic exercise capacity is tightly associated with mortality across many complex diseases. The premise is supported by recent studies demonstrating that smokers who exercise regularly are less likely to develop or be hospitalized for COPD. Herein, we describe the evolutionary and molecular basis for this hypothesis and how it is a natural extension of previous theories explaining COPD susceptibility.
慢性阻塞性肺疾病是发病率和死亡率的主要原因，它通常与吸烟或暴露于环境污染物有关。不幸的是，人们对导致个体易患 COPD 的分子和生理决定因素的认识还不够充分。在这里，我们提出一个新的假设：在接触关键风险因素后，有氧运动能力本身较低的个体更有可能患上 COPD。这个假设是基于这样的观察结果，即有氧运动能力与许多复杂疾病的死亡率密切相关。最近的研究也支持了这一前提，这些研究表明，经常锻炼的吸烟者患 COPD 或因 COPD 住院的可能性较小。本文描述了这一假设的进化和分子基础，以及它如何是解释 COPD 易感性的先前理论的自然延伸。
