Pye M, Rae A P, Hutton I, Cobbe S M
Department of Medical Cardiology, Royal Infirmary, Glasgow, U.K.
Int J Cardiol. 1990 Apr;27(1):101-6. doi: 10.1016/0167-5273(90)90196-c.
In a prospective blind study, continuous and pulsed wave Doppler echocardiography were used to predict the severity of angiographically assessed aortic regurgitation in 36 patients. High quality continuous wave spectral recordings of the regurgitant jet were obtained in 32 patients but four patients with mild aortic regurgitation had dropout of high velocity signals precluding accurate assessment. The deceleration slope of the peak to end-diastolic velocity measured by continuous wave Doppler, and pulsed wave Doppler mapping of the regurgitant jet in the left ventricle were compared with angiographic severity. The deceleration slope was significantly steeper in patients with severe rather than mild or moderate aortic regurgitation (3.65 +/- 1.04 vs. 1.89 +/- 0.42 vs. 1.52 +/- 0.59 m sec-2). A decay slope of greater than 3 m sec-2 was observed only in patients with 3+ or 4+ aortic regurgitation and a decay slope less than 1.2 m sec-2 was seen only in mild 1+ aortic regurgitation but there was considerable overlap between groups, making it difficult in individual cases to assess severity on the basis of the continuous wave deceleration slope. The pulsed wave Doppler technique was more time consuming, added little to the continuous wave Doppler assessment and underestimated severe regurgitation in almost 50% of cases. Hence, there are significant problems using either Doppler technique in quantitatively assessing aortic regurgitation.
在一项前瞻性盲法研究中,采用连续波和脉冲波多普勒超声心动图对36例患者经血管造影评估的主动脉瓣反流严重程度进行预测。32例患者获得了高质量的反流束连续波频谱记录,但4例轻度主动脉瓣反流患者出现高速信号丢失,无法进行准确评估。将连续波多普勒测量的舒张末期峰值速度减速斜率以及左心室内反流束的脉冲波多普勒映射与血管造影严重程度进行比较。重度主动脉瓣反流患者的减速斜率明显比轻度或中度患者更陡(3.65±1.04对1.89±0.42对1.52±0.59米/秒²)。仅在3+或4+级主动脉瓣反流患者中观察到大于3米/秒²的衰减斜率,仅在轻度1+级主动脉瓣反流患者中观察到小于1.2米/秒²的衰减斜率,但各组之间存在相当大的重叠,使得在个别病例中难以根据连续波减速斜率评估严重程度。脉冲波多普勒技术耗时更长,对连续波多普勒评估的补充作用不大,并且在近50%的病例中低估了重度反流。因此,使用任何一种多普勒技术在定量评估主动脉瓣反流方面都存在重大问题。