Dittmann H, Karsch K R, Seipel L
Z Kardiol. 1986 Sep;75(9):522-7.
To test the capacity of pulsed Doppler echocardiography in the detection and quantification of aortic regurgitation, 64 consecutive patients with aortic and mitral valve disease were examined clinically and by echocardiography before cardiac catheterization. The severity of aortic regurgitation was determined angiographically (I-IV) and compared with the extent of the regurgitant jet in the left ventricle measured by pulsed Doppler echocardiography. In 15 of 64 patients neither angiography nor pulsed Doppler echocardiography showed aortic regurgitation (specificity 100%). Apart from 3 patients with poor echo quality pulsed Doppler echocardiography correctly detected aortic regurgitation in 46 of 49 patients (sensitivity 94%). Clinical examination (63%) and M-mode echocardiography (63%) were significantly less sensitive than Doppler echocardiography (p less than 0.001). The pulsed Doppler echocardiographic degree of aortic regurgitation correlated strongly with angiography (corrected contingency coefficient 0.91). In patients with severe aortic stenosis (systolic gradient greater than 50 mm Hg) aortic regurgitation I was slightly overestimated by pulsed Doppler echocardiography (p less than 0.003). Differentiation of aortic regurgitation III and IV was not possible. Mitral valve disease did not affect quantification of aortic regurgitation (n = 23).
为测试脉冲多普勒超声心动图检测和定量主动脉瓣反流的能力，在心脏导管插入术前，对64例连续的主动脉瓣和二尖瓣疾病患者进行了临床检查和超声心动图检查。通过血管造影确定主动脉瓣反流的严重程度（I-IV级），并与脉冲多普勒超声心动图测量的左心室反流束范围进行比较。64例患者中有15例血管造影和脉冲多普勒超声心动图均未显示主动脉瓣反流（特异性100%）。除3例回声质量差的患者外，脉冲多普勒超声心动图在49例患者中的46例中正确检测到主动脉瓣反流（敏感性94%）。临床检查（63%）和M型超声心动图（63%）的敏感性明显低于多普勒超声心动图（p<0.001）。脉冲多普勒超声心动图测定的主动脉瓣反流程度与血管造影密切相关（校正列联系数0.91）。在严重主动脉瓣狭窄（收缩期压差大于50 mmHg）的患者中，脉冲多普勒超声心动图对I级主动脉瓣反流有轻微高估（p<0.003）。无法区分III级和IV级主动脉瓣反流。二尖瓣疾病不影响主动脉瓣反流的定量（n = 23）。
