Tei C, Kisanuki A, Arikawa K, Otsuji Y, Arima S, Kashima T, Tanaka H, Kushitani M, Shah P M
J Cardiogr. 1985 Mar;15(1):111-21.
Twenty-four patients with aortic stenosis and 22 with aortic insufficiency were evaluated using continuous wave Doppler echocardiography (echo). Doppler echo studies were performed 48 hours before cardiac catheterization. Fifteen normal subjects served as controls. Peak velocity in the ascending aorta in aortic stenosis ranged from 2.0 to 6.0 m/sec with a mean of 3.7 m/sec, and this was significantly increased over the normal controls (mean 1.1 m/sec: 0.7-1.4 m/sec). Using the simplified Bernoulli equation (P = 4 V2, P: peak pressure gradient, V: peak flow velocity), the peak pressure gradient across the aortic valve was measured from the peak velocity in patients with aortic stenosis. The results (Y) correlated well with the peak-to-peak pressure gradient (X) between the left ventricular pressure and aortic pressure as obtained by cardiac catheterization (Y = 1.1 X +2.5, r = 0.83). Aortic regurgitation was detected by continuous wave Doppler echo in all patients with aortic insufficiency, but in only half of the patients the peak velocity could be measured (3.8 +/- 0.3 m/sec, mean +/- SD). In the remaining patients, it was difficult to measure the peak velocity, but it seemed to be greater than 3.0 m/sec. On the simultaneous recordings of the gradient between aortic and left ventricular pressures and continuous wave Doppler echo in patients with aortic regurgitation, the shape and pattern of the pressure gradient during diastole were similar to those of continuous wave Doppler echo. We conclude that continuous wave Doppler echo is a very sensitive method for diagnosing aortic stenosis and regurgitation, and it provides a quantitative assessment of the severity of aortic stenosis.
采用连续波多普勒超声心动图(超声)对24例主动脉瓣狭窄患者和22例主动脉瓣关闭不全患者进行了评估。在心脏导管插入术前48小时进行了多普勒超声研究。15名正常受试者作为对照。主动脉瓣狭窄患者升主动脉的峰值流速为2.0至6.0米/秒,平均为3.7米/秒,这明显高于正常对照组(平均1.1米/秒:0.7 - 1.4米/秒)。使用简化的伯努利方程(P = 4V²,P:峰值压力阶差,V:峰值流速),根据主动脉瓣狭窄患者的峰值流速测量主动脉瓣跨瓣峰值压力阶差。结果(Y)与通过心脏导管插入术获得的左心室压力和主动脉压力之间的峰 - 峰压力阶差(X)密切相关(Y = 1.1X + 2.5,r = 0.83)。通过连续波多普勒超声在所有主动脉瓣关闭不全患者中均检测到主动脉瓣反流,但仅半数患者可测量到峰值流速(3.8±0.3米/秒,平均值±标准差)。在其余患者中,难以测量峰值流速,但似乎大于3.0米/秒。在主动脉瓣反流患者中同时记录主动脉和左心室压力之间的阶差以及连续波多普勒超声时,舒张期压力阶差的形状和模式与连续波多普勒超声相似。我们得出结论,连续波多普勒超声是诊断主动脉瓣狭窄和反流的非常敏感的方法,并且它提供了对主动脉瓣狭窄严重程度的定量评估。