St. John's Medical College Hospital, Bangalore, India.
Psychopharmacology (Berl). 2013 May;227(2):299-306. doi: 10.1007/s00213-013-2978-z. Epub 2013 Jan 26.
A number of studies have indicated positive effects of long-term administration (3 months) of Bacopa monniera (Brahmi) on various cognitive functions especially memory and anxiety. However, inconsistent results in literature may be linked to various methodological issues.
The present study aimed to test the chronic effects (12 weeks) of 450 mg of a B. monniera (Brahmi) extract on learning and memory, information processing and anxiety in healthy adult Indian population.
The study design was a randomised, double-blind, placebo-controlled parallel design. Participants comprised of 72 healthy urban adults, both men and women, in the age range of 35-60 years who were educated and English speaking with basic knowledge of computers from Bangalore. The outcome measures included verbal learning and memory, inspection time, attention and interference. State and trait anxiety were additional outcome variables.
In the present study, there were no significant differences between the two groups on any of the cognitive measures. However, there was a trend for lower state anxiety in the B. monniera (Brahmi) group as compared to placebo group.
The current study attempted to determine the chronic effects of single daily dose of 450 mg of Brahmi extract on cognitive performance and anxiety in healthy adults. The results of the current study are not in agreement with findings of some of the earlier studies which have found improvement both on cognitive parameters and a reduction of anxiety scores.
多项研究表明，长期（3 个月）服用益智草（Brahmi）对各种认知功能，特别是记忆和焦虑有积极影响。然而，文献中的不一致结果可能与各种方法学问题有关。
本研究旨在测试 450mg 益智草（Brahmi）提取物对健康成年印度人群的学习和记忆、信息处理和焦虑的慢性影响（12 周）。
该研究设计为随机、双盲、安慰剂对照的平行设计。参与者包括 72 名年龄在 35-60 岁之间的健康城市成年人，男女皆有，受过教育，会说英语，对计算机有基本的了解，均来自班加罗尔。主要的结果评估包括语言学习和记忆、检查时间、注意力和干扰。状态和特质焦虑也是额外的结果变量。
在本研究中，两组在任何认知测量上都没有显著差异。然而，与安慰剂组相比，益智草（Brahmi）组的状态焦虑较低，这只是一种趋势。
本研究试图确定每日一次服用 450mg 益智草提取物对健康成年人的认知表现和焦虑的慢性影响。本研究的结果与一些早期研究的发现不一致，这些研究发现认知参数和焦虑评分都有改善。
