Department of Urology, The Tenth People's Hospital Affiliated to Tongji University, Shanghai 200072, China.
Cancer Lett. 2013 Jun 10;333(2):213-21. doi: 10.1016/j.canlet.2013.01.033. Epub 2013 Jan 24.
lncRNA H19 is essential for human tumor growth. However, little is known about whether H19 regulates bladder cancer metastasis. Here we found that H19 levels are remarkably increased in bladder cancer tissues, and upregulated H19 promotes bladder cancer cell migration in vitro and in vivo. H19 is associated with enhancer of zeste homolog 2 (EZH2), and that this association results in Wnt/β-catenin activation and subsequent downregulation of E-cadherin. A significant negative correlation is also observed between H19 levels and E-cad levels in vivo. These data suggest that upregulated H19 enhances bladder cancer metastasis by associating with EZH2 and inhibiting E-cad expression.
长链非编码 RNA H19 对人类肿瘤生长至关重要。然而，目前尚不清楚 H19 是否调节膀胱癌转移。在这里，我们发现 H19 在膀胱癌组织中显著增加，上调的 H19 促进膀胱癌细胞在体外和体内迁移。H19 与 EZH2 相关，这种关联导致 Wnt/β-catenin 激活，随后下调 E-cadherin。体内还观察到 H19 水平与 E-cad 水平之间存在显著的负相关。这些数据表明，上调的 H19 通过与 EZH2 结合并抑制 E-cad 表达来增强膀胱癌的转移。
