Loughran John H, Chugh Atul R, Ismail Imtiaz, Bolli Roberto
Division of Cardiovascular Medicine, University of Louisville, 550 S Jackson Street ACB Bldg, 3rd Floor, Louisville, KY 40202, USA.
Curr Heart Fail Rep. 2013 Mar;10(1):73-80. doi: 10.1007/s11897-012-0128-2.
Cardiac repair through the use of regenerative medicine has been a considerable research focus over the last decade. Several stem cell types have been investigated over this timeframe as potential candidates to target post-infarction heart failure. The progression of investigation through the rigors of clinical trial design has provided some answers as to the potential clinical utility of this therapy; although there are many questions that remain. This review will concentrate on the clinical trial results of stem cell therapy for cardiac repair since the turn of the century and discuss some of the points that need clarification before this form of therapy can be considered for widespread applicability.
在过去十年中，通过再生医学进行心脏修复一直是相当受关注的研究焦点。在此期间，人们研究了几种干细胞类型，将其作为治疗心肌梗死后心力衰竭的潜在候选方法。通过严格的临床试验设计进行的研究进展，为这种疗法的潜在临床应用提供了一些答案；尽管仍有许多问题有待解决。本综述将聚焦自世纪之交以来干细胞治疗心脏修复的临床试验结果，并讨论在这种治疗方法可被认为具有广泛适用性之前需要澄清的一些要点。
