Patterson J F
Psychiatry Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201.
J Clin Psychiatry. 1990 May;51 Suppl:47-9; discussion 50-3.
Clinical observations of 37 alprazolam-dependent patients are presented. Seventeen inpatients and 20 outpatients, the majority suffering from posttraumatic stress disorder, were withdrawn from alprazolam by means of clonazepam substitution in an open-label fashion. Two patients experienced rebound panic symptoms; true withdrawal syndromes were not observed. Although the limitations of an open series are evident, it was found that this method of discontinuation is safe and effective and, in particular, does not pose a danger of withdrawal seizures.
本文介绍了对37例阿普唑仑依赖患者的临床观察。17例住院患者和20例门诊患者，大多数患有创伤后应激障碍，以开放标签的方式通过氯硝西泮替代使他们停用阿普唑仑。2例患者出现了惊恐症状反弹；未观察到真正的戒断综合征。尽管开放系列研究存在明显局限性，但发现这种停药方法是安全有效的，特别是不会带来戒断性癫痫发作的风险。
