Popov S V, Melekhovets' O K, Demikhova N V, Vynnychenko L B
Lik Sprava. 2012 Apr-Jun(3-4):75-81.
Left ventricular diastolic dysfunction in patients with diabetes is formed in the absence of atherosclerotic changes as a consequence of diabetic cardiac autonomic neuropathy in the early stages of diabetes. Progression of autonomic cardiac neuropathy in cardio-vascular type is associated with the violation of energy supply of cells, protein synthesis, electrolyte exchange, the exchange of trace elements, oxidation reduction processes, oxygen-transport function of blood, so that metabolic therapy is carried out to optimize the processes of formation and energy costs. The drug cocarnit activates processes of aerobic oxidation of glucose, as well as providing regulatory influence on the oxidation of fatty acids. Applying of cocarnit in complex therapy in patients with diabetic cardiac autonomic neuropathy found improvement of left ventricular diastolic function, and positive dynamics in the efferent activity balance of the sympathetic and parasympathetic control of heart rate variability, which provides the regression of clinical symptoms.
糖尿病患者的左心室舒张功能障碍在糖尿病早期因糖尿病性心脏自主神经病变而在无动脉粥样硬化改变的情况下形成。心血管型自主神经病变的进展与细胞能量供应、蛋白质合成、电解质交换、微量元素交换、氧化还原过程、血液氧运输功能的破坏有关，因此进行代谢治疗以优化形成过程和能量消耗。药物辅酶肉碱可激活葡萄糖的有氧氧化过程，并对脂肪酸氧化产生调节作用。在糖尿病性心脏自主神经病变患者的综合治疗中应用辅酶肉碱，发现左心室舒张功能得到改善，心率变异性的交感和副交感控制的传出活动平衡呈现积极变化，这使得临床症状消退。
