Korzh N A, Filippenko V A, Leont'eva F S, Tulyakov V A, Bondarenko S E
Lik Sprava. 2015 Jul-Sep(5-6):126-32.
In the article the results of clinical researches of efficiency of preparation of Cocarnit are resulted for patients after endoprosthesis of large joints. It is routine that for patients, receiving preparation of Cocarnit after the operation period there was a decline in the amount of complaints of patients on the total somatical state. Preparation of Ccocarnit was positively estimated outside patients, meaningful by-reactions, serving reason of abolition of preparation, was not marked. At the reception preparation of Cocarnit greater part of investigational laboratory indexes (table of contents of glucose, β-lipoproteines, total chondroitisulfates, TBC-productes (malonic dyaldehyde), activity of aspartataminotransferase, alkaline phosphatase and β-glutamyltranspeptidase), the indexes of clinical blood test and leucocytar indexes during a supervision did not have reliable differences from such as the persons of the control group, that confirms good bearab leness of the indicated preparation. Application preparation of Cocarnit for patients in composition the chart of treatment of patients after endoprosthesis of large joints brought maintenance over of cholesterol to the decline, glycoproteins, TBC-products (malonic dyaldehyde), activity of alaninaminotransferase, that specifies on normalizing influence of the indicated preparation in relation to the basic types of exchange of matters.
文章给出了大关节置换术后患者使用左卡尼汀制剂疗效的临床研究结果。通常，在术后接受左卡尼汀制剂治疗的患者中，患者对总体躯体状况的投诉量有所下降。左卡尼汀制剂在患者外部得到了积极评价，未发现有意义的副反应，也没有因副反应而停用制剂的情况。在接受左卡尼汀制剂治疗期间，大部分研究实验室指标（血糖、β脂蛋白、总软骨素硫酸盐、TBC产物（丙二醛）、天冬氨酸转氨酶、碱性磷酸酶和β-谷氨酰转肽酶的含量表）、临床血液检测指标和白细胞指标与对照组人员相比没有可靠差异，这证实了该制剂具有良好的耐受性。在大关节置换术后患者的治疗方案中应用左卡尼汀制剂，可使胆固醇、糖蛋白、TBC产物（丙二醛）、丙氨酸转氨酶活性下降，这表明该制剂对物质代谢的基本类型具有正常化作用。
