Department of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, 60131, Ancona, Italy.
Biochem Soc Trans. 2013 Feb 1;41(1):350-5. doi: 10.1042/BST20120300.
The formation of the translation initiation complex represents the rate-limiting step in protein synthesis. Translation initiation in the crenarchaeon Sulfolobus solfataricus depends on several translation IFs (initiation factors), some of which have eukaryal but no bacterial counterparts. In the present paper, we review the current knowledge of the structure, function and evolution of the IFs in S. solfataricus in the context of eukaryotic and bacterial orthologues. Despite similarities between eukaryotic and S. solfataricus IFs, the sequence of events in translation initiation in S. solfataricus follows the bacterial mode.
翻译起始复合物的形成是蛋白质合成的限速步骤。 泉古菌 Sulfolobus solfataricus 的翻译起始依赖于几种翻译 IF（起始因子），其中一些具有真核生物但没有细菌对应物。 在本文中，我们在真核生物和细菌同源物的背景下综述了 S. solfataricus 的 IF 结构、功能和进化的最新知识。 尽管真核生物和 S. solfataricus 的 IF 之间存在相似性，但 S. solfataricus 翻译起始的事件顺序遵循细菌模式。
