Wang Meng, Wang Zhi-Ping, Gao Li-Jie, Gong Rui, Zhang Meng, Lu Qing-Bin, Zhao Zhong-Tang
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, Shandong, China.
J Matern Fetal Neonatal Med. 2013 Jul;26(11):1132-8. doi: 10.3109/14767058.2013.770461. Epub 2013 Mar 1.
To explore the periconceptional factors affecting the risk of neural tube defects (NTDs), we carried out a hospital-based case-control study in China.
A 1:1 matched case-control study was conducted. With self-designed questionnaires, we solicited relevant information from 459 case mothers and 459 control mothers selected in two provinces of China through face-to-face interviews. Univariate and multivariate conditional logistic regression analyses were conducted to evaluate the effect values by odds ratios (ORs) and 95% confidence intervals (95%CIs) with SAS9.1.3.software.
Daily passive tobacco smoke exposure was a risk factor for total NTDs (OR = 8.688, 95%CI = 2.329-32.404). Diet adjustment in the first trimester (OR = 0.061, 95%CI = 0.014-0.274), periconceptional folic acid intake (OR = 0.059, 95%CI = 0.011-0.321) and health education (OR = 0.251, 95%CI = 0.081-0.781) were protective factors for total NTDs. Differences in factors and their effects on NTDs were found for the three subtypes of NTDs: anencephaly, spina bifida and encephalocele.
Daily passive tobacco smoke exposure, diet adjustment in the first trimester, periconceptional folic acid intake and health education were associated with NTDs.
为探讨影响神经管缺陷（NTDs）风险的受孕前后因素，我们在中国开展了一项基于医院的病例对照研究。
进行了一项1:1匹配的病例对照研究。通过自行设计的问卷，我们对在中国两个省份选取的459例病例母亲和459例对照母亲进行面对面访谈，收集相关信息。使用SAS9.1.3软件，通过单因素和多因素条件logistic回归分析，以比值比（OR）和95%置信区间（95%CI）评估效应值。
每日被动吸烟是总神经管缺陷的一个危险因素（OR = 8.688，95%CI = 2.329 - 32.404）。孕早期饮食调整（OR = 0.061，95%CI = 0.014 - 0.274）、受孕前后叶酸摄入（OR = 0.059，95%CI = 0.011 - 0.321）和健康教育（OR = 0.251，95%CI = 0.081 - 0.781）是总神经管缺陷的保护因素。在神经管缺陷的三种亚型：无脑儿、脊柱裂和脑膨出中，发现了因素及其对神经管缺陷影响的差异。
每日被动吸烟、孕早期饮食调整、受孕前后叶酸摄入和健康教育与神经管缺陷有关。
