Wang Meng, Wang Zhi-Ping, Gao Li-Jie, Yang Hui, Zhao Zhong-Tang
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 WenhuaXilu Road, Jinan 250012, Shandong, China.
Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, Zhejiang, China.
Nutrients. 2015 Apr 24;7(5):3067-77. doi: 10.3390/nu7053067.
To study the associations between maternal consumption of non-staple food in the first trimester and risk of neural tube defects (NTDs) in offspring. Data collected from a hospital-based case-control study conducted between 2006 and 2008 in Shandong/Shanxi provinces including 459 mothers with NTDs-affected births and 459 mothers without NTDs-affected births. Logistic regression models were used to examine the associations between maternal consumption of non-staple food in the first trimester and risk of NTDs in offspring. The effects were evaluated by odds ratio (OR) and 95% confidence intervals (95% CIs) with SAS9.1.3.software. Maternal consumption of milk, fresh fruits and nuts in the first trimester were protective factors for total NTDs. Compared with consumption frequency of ˂1 meal/week, the ORs for milk consumption frequency of 1-2, 3-6, ≥7 meals/week were 0.50 (95% CI: 0.28-0.88), 0.56 (0.32-0.99), and 0.59 (0.38-0.90), respectively; the ORs for fresh fruits consumption frequency of 1-2, 3-6, ≥7 meals/week were 0.29 (95% CI: 0.12-0.72), 0.22 (0.09-0.53), and 0.32 (0.14-0.71), respectively; the ORs for nuts consumption frequency of 1-2, 3-6, ≥7 meals/week were 0.60 (95% CI: 0.38-0.94), 0.49 (0.31-0.79), and 0.63 (0.36-1.08), respectively. Different effects of above factors on NTDs were found for subtypes of anencephaly and spina bifida. Maternal non-staple food consumption of milk, fresh fruits and nuts in the first trimester was associated with reducing NTDs risk in offspring.
研究孕早期母亲非主食摄入与子代神经管缺陷（NTDs）风险之间的关联。数据来自2006年至2008年在山东/山西省开展的一项基于医院的病例对照研究，包括459例生育NTDs患儿的母亲和459例未生育NTDs患儿的母亲。采用逻辑回归模型检验孕早期母亲非主食摄入与子代NTDs风险之间的关联。使用SAS9.1.3软件通过比值比（OR）和95%置信区间（95% CIs）评估效应。孕早期母亲摄入牛奶、新鲜水果和坚果是总NTDs的保护因素。与每周食用次数<1次相比，每周食用牛奶1 - 2次、3 - 6次、≥7次的OR分别为0.50（95% CI：0.28 - 0.88）、0.56（0.32 - 0.99）和0.59（0.38 - 0.90）；每周食用新鲜水果1 - 2次、3 - 6次、≥7次的OR分别为0.29（95% CI：0.12 - 0.72）、0.22（0.09 - 0.53）和0.32（0.14 - 0.71）；每周食用坚果1 - 2次、3 - 6次、≥7次的OR分别为0.60（95% CI：0.38 - 0.94）、0.49（0.31 - 0.79）和0.63（0.36 - 1.08）。上述因素对无脑儿和脊柱裂亚型的NTDs有不同影响。孕早期母亲摄入牛奶、新鲜水果和坚果与降低子代NTDs风险有关。
