Madison K M, Bowen W H, Pearson S K, Falany J L
University of Rochester, Department of Dental Research, New York 14642.
J Dent Res. 1990 May;69(5):1154-9. doi: 10.1177/00220345900690050701.
The purpose of this study was to determine the influence of caging desalivated S. sobrinus-infected rats on the caries incidence in intact, previously uninfected cagemates. Weanlings were divided as follows: Stage I: Twenty desalivated animals paired with 20 intact animals (Group I); 20 intact animals paired with 20 intact animals (Group II). Animals were infected with S. sobrinus and fed diet 2000 and 10% sucrose water. After five weeks, ten paired animals from each group were killed. Desalivated animals had statistically higher (p less than 0.05) caries scores than did other animals. Stage II: The remaining Stage I infected animals from Groups I and II were paired with 40 new uninfected animals 15 days of age and fed cariogenic diets. After five weeks, new intact animals paired with Stage I desalivated animals had significantly higher smooth-surface enamel caries scores (38.0; SE 7.84) than new intact animals paired with Stage I intact animals (11.15; SE 3.69). Moreover, new intact animals caged for only five weeks with Stage I desalivated animals developed smooth-surface caries (38.0; SE 7.84) to a degree comparable with that in all Stage I intact animals in the experiment for ten weeks (36.6, SE 9.5; and 30.05, SE 4.1). The data suggest that desalivation may select a readily transmissible strain of S. sobrinus, which demonstrates enhanced virulence.
本研究的目的是确定将感染了远缘链球菌的去唾液大鼠关在笼中，对其未感染的完整同笼伙伴龋齿发病率的影响。断奶幼鼠分为以下几组：第一阶段：20只去唾液动物与20只完整动物配对（第一组）；20只完整动物与20只完整动物配对（第二组）。动物感染远缘链球菌，喂食2000号饲料和10%的蔗糖水。五周后，每组处死十对动物。去唾液动物的龋齿评分在统计学上高于其他动物（p小于0.05）。第二阶段：第一阶段第一组和第二组中剩余的感染动物与40只15日龄的未感染新动物配对，并喂食致龋饮食。五周后，与第一阶段去唾液动物配对的新完整动物的平滑面釉质龋齿评分（38.0；标准误7.84）显著高于与第一阶段完整动物配对的新完整动物（11.15；标准误3.69）。此外，仅与第一阶段去唾液动物同笼饲养五周的新完整动物发生的平滑面龋齿（38.0；标准误7.84）程度，与实验中第一阶段所有完整动物十周时的情况相当（36.6，标准误9.5；以及30.05，标准误4.1）。数据表明，去唾液可能会选择一种易于传播的远缘链球菌菌株，该菌株表现出更强的毒力。
