Department of Chemistry, Umeå University, Umeå SE-901 87, Sweden.
Biotechnol Biofuels. 2013 Jan 28;6(1):16. doi: 10.1186/1754-6834-6-16.
Bioconversion of lignocellulose by microbial fermentation is typically preceded by an acidic thermochemical pretreatment step designed to facilitate enzymatic hydrolysis of cellulose. Substances formed during the pretreatment of the lignocellulosic feedstock inhibit enzymatic hydrolysis as well as microbial fermentation steps. This review focuses on inhibitors from lignocellulosic feedstocks and how conditioning of slurries and hydrolysates can be used to alleviate inhibition problems. Novel developments in the area include chemical in-situ detoxification by using reducing agents, and methods that improve the performance of both enzymatic and microbial biocatalysts.
微生物发酵转化木质纤维素通常需要进行酸性热化学预处理步骤，以促进纤维素的酶水解。木质纤维素原料预处理过程中形成的物质会抑制酶水解和微生物发酵步骤。本文综述了木质纤维素原料中抑制剂的种类，以及如何通过调节悬浮液和水解液来缓解抑制问题。该领域的新进展包括使用还原剂进行原位化学解毒，以及提高酶和微生物生物催化剂性能的方法。
