Glass E G, Lawton L R, Truelove E L
Department of Oral Diagnosis, University of Missouri-Kansas City School of Dentistry 64108-2795.
J Am Dent Assoc. 1990 May;120(5):523-5. doi: 10.14219/jada.archive.1990.0067.
Although the mouth is often involved in Wegener granulomatosis, oral lesions as the initial sign are rare. This case report documents the importance of considering Wegener granulomatosis in patients with unique oral lesions. The most common lesion is a friable-granular-hyperplastic gingivitis associated with alveolar resorption and tooth mobility. The disease may remain localized to the mouth for several weeks or months before multiorgan involvement occurs. Gingival enlargement is a direct manifestation of Wegener granulomatosis, and it may be pathognomonic. Failure to recognize the clinical lesions can result in delayed diagnosis and treatment, with potentially fatal results.
虽然韦格纳肉芽肿病常累及口腔，但以口腔病变为首发症状者罕见。本病例报告证明了对于有独特口腔病变的患者考虑韦格纳肉芽肿病的重要性。最常见的病变是与牙槽骨吸收和牙齿松动相关的易碎颗粒状增生性牙龈炎。在多器官受累之前，该病可能局限于口腔数周或数月。牙龈肿大是韦格纳肉芽肿病的直接表现，可能具有诊断特异性。未能识别临床病变可导致诊断和治疗延迟，可能产生致命后果。
