Lv Bin, Cheng Zhangrong, Yu Yajie, Chen Yuhang, Gan Weikang, Li Shuai, Zhao Kangcheng, Yang Cao, Zhang Yukun
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Surg. 2022 Aug 2;9:836367. doi: 10.3389/fsurg.2022.836367. eCollection 2022.
Exosomes are widely involved in a variety of physiological and pathological processes. These important roles are also hidden in the physiological processes related to bone. Chondrocytes, osteoblasts, synovial fibroblasts, and bone marrow mesenchymal stem cells produce and secrete exosomes, thereby affecting the biology process of target cells. Furthermore, in the primary pathogenesis of osteoarthrosis induced by steroid hormones, mainly involve glucocorticoid (GC), the exosomes have also widely participated. Therefore, exosomes may also play an important role in glucocorticoid-induced osteoarthrosis and serve as a promising treatment for early intervention of osteoarthrosis in addition to playing a regulatory role in malignant tumors. This review summarizes the previous results on this direction, systematically combs the role and therapeutic potential of exosomes in GC-induced osteoarthrosis, discusses the potential role of exosomes in the treatment and prevention of GC-induced osteoarthrosis, and reveals the current challenges we confronted.
外泌体广泛参与多种生理和病理过程。这些重要作用也隐藏在与骨骼相关的生理过程中。软骨细胞、成骨细胞、滑膜成纤维细胞和骨髓间充质干细胞产生并分泌外泌体，从而影响靶细胞的生物学过程。此外，在主要由糖皮质激素（GC）诱导的骨关节炎的原发性发病机制中，外泌体也广泛参与其中。因此，外泌体可能在糖皮质激素诱导的骨关节炎中也发挥重要作用，并且除了在恶性肿瘤中发挥调节作用外，还可作为骨关节炎早期干预的一种有前景的治疗方法。本综述总结了此前在该方向上的研究结果，系统梳理了外泌体在GC诱导的骨关节炎中的作用及治疗潜力，探讨了外泌体在GC诱导的骨关节炎治疗和预防中的潜在作用，并揭示了我们目前面临的挑战。
