猪基因型 3 肝炎病毒的亚型。

Subtypes of genotype 3 hepatitis E virus in pigs.

机构信息

Key Laboratory of Public Health Safety of the Ministry of Education, Department of Epidemiology, Fudan University School of Public Health, Shanghai 200032, China.

出版信息

Vet J. 2013 Aug;197(2):509-11. doi: 10.1016/j.tvjl.2012.12.023. Epub 2013 Jan 26.

DOI:10.1016/j.tvjl.2012.12.023

PMID:23357066

Abstract

The prevalence of hepatitis E virus (HEV) RNA in faecal and bile samples from pigs in abattoirs in Eastern and South Western China from 2006 to 2011 was determined by reverse transcriptase PCR. HEV-3 was detected in 4/5952 (0.07%) pigs and HEV-4 was detected in 287/5952 (4.8%) pigs. Two HEV-3 subtype 3a strains from South Western China had 87.1-89.7% sequence identity. Two HEV-3 subtype 3b strains from Eastern China had 91.8-93.8% sequence identity and were similar to strains reported previously in Eastern and Central China. The distinct subtypes of HEV-3 in different regions of China suggested multiple origins of HEV infection.

摘要

2006 年至 2011 年，采用逆转录聚合酶链反应（RT-PCR）方法检测了来自中国华东和华南地区屠宰场的猪粪便和胆汁样本中戊型肝炎病毒（HEV）RNA 的流行情况。在 5952 份猪粪便样本中检测到 4 份 HEV-3（0.07%），在 5952 份胆汁样本中检测到 287 份 HEV-4（4.8%）。来自中国西南部的 2 株 HEV-3 亚型 3a 株与其他地区的 3a 株的核苷酸序列同源性为 87.1%-89.7%。来自中国东部的 2 株 HEV-3 亚型 3b 株与其他地区的 3b 株的核苷酸序列同源性为 91.8%-93.8%，与之前报道的中国东部和中部地区的 3b 株相似。中国不同地区存在不同的 HEV-3 亚型，提示 HEV 感染存在多个来源。