Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India.
J Genet Genomics. 2013 Jan 20;40(1):15-22. doi: 10.1016/j.jgg.2012.12.001. Epub 2012 Dec 26.
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world today. Its incidence in adults and children is rising rapidly due to the ongoing epidemics of obesity and type 2 diabetes. Hence, it has become a global public health issue. Environmental factors have been found to play a major role in the etiology of NAFLD, especially for genetically susceptible populations. Among these, one of the most important factors is junk food, especially the typical "Western-style" diet rich in simple carbohydrates, saturated fat, and highly processed food materials. Genetic predisposition to NAFLD does occur; however, a precise definition of genetic factors responsible for NAFLD is still lacking. Specific variants of different genes have been shown to present a risk for NAFLD. Genetic studies might be helpful in the management of the disease by developing novel treatment strategies based on individual's genotype.
非酒精性脂肪性肝病（NAFLD）是当今世界最常见的肝脏疾病。由于肥胖症和 2 型糖尿病的持续流行，其在成年人和儿童中的发病率正在迅速上升。因此，它已成为一个全球性的公共卫生问题。环境因素被发现对 NAFLD 的病因学起着重要作用，特别是对于遗传易感人群。在这些因素中，最重要的因素之一是垃圾食品，尤其是富含简单碳水化合物、饱和脂肪和高度加工食品的典型“西式”饮食。NAFLD 确实存在遗传易感性；然而，导致 NAFLD 的遗传因素的确切定义仍然缺乏。不同基因的特定变体已被证明存在患 NAFLD 的风险。通过基于个体基因型开发新的治疗策略，遗传研究可能有助于疾病的管理。
