Mirmiran Parvin, Amirhamidi Zeynab, Ejtahed Hanieh-Sadat, Bahadoran Zahra, Azizi Fereidoun
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2017 Aug;46(8):1007-1017.
Diet plays a key role in the development of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to review systematically observational studies available regarding the relationship between food intakes and NAFLD.
We searched Scopus, PubMed, and Cochrane Library databases to identify English observational studies on food groups, dietary patterns, and NAFLD. Cross-sectional, case-control and cohort studies were selected and then duplication, topic, type of study, study population, variables examined and quality of data reporting of the articles were evaluated.
We identified 2128 studies in the initial search, of which 33 were reviewed in full text and 7 articles were included in this systematic review. Intakes of red meat, fats, and sweets were high whereas consumption of whole grains, fruits and vegetables were less in NAFLD patients. Moreover, there was a positive association between the Western dietary pattern and the risk of NAFLD, while adherence to the Mediterranean diet was significantly associated with the severity of hepatic steatosis.
Generally, different food group intakes and dietary patterns are associated with the progression of NAFLD and its risk factors. Because of the many limitations of available studies reviewed on this topic, more prospective studies are suggested.
饮食在非酒精性脂肪性肝病（NAFLD）的发展中起关键作用。本研究的目的是系统回顾关于食物摄入量与NAFLD之间关系的现有观察性研究。
我们检索了Scopus、PubMed和Cochrane图书馆数据库，以识别关于食物类别、饮食模式和NAFLD的英文观察性研究。选择横断面研究、病例对照研究和队列研究，然后对文章的重复性、主题、研究类型、研究人群、所检查的变量以及数据报告质量进行评估。
在初步检索中我们识别出2128项研究，其中33项进行了全文回顾，7篇文章纳入了本系统评价。NAFLD患者红肉、脂肪和甜食的摄入量较高，而全谷物、水果和蔬菜的摄入量较少。此外，西方饮食模式与NAFLD风险之间存在正相关，而坚持地中海饮食与肝脂肪变性的严重程度显著相关。
一般来说，不同食物类别的摄入量和饮食模式与NAFLD的进展及其危险因素相关。由于关于该主题的现有研究所存在的诸多局限性，建议开展更多前瞻性研究。
