Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Exp Anim. 2013;62(1):63-9. doi: 10.1538/expanim.62.63.
A combination of hematoma aspiration and local delivery of chemicals may be more effective than either therapy in intracerebral hemorrhage (ICH). The aim of the present study was to develop a rat model of hematoma aspiration plus intralesional injection after ICH. ICH was induced in adult Sprague-Dawley rats by an intrastriatal injection of bacterial collagenase IV. Hematoma aspiration was performed 3.5 h after ICH onset. Following aspiration, normal saline was injected into the lesion cavity. Hematoma aspiration with or without subsequent saline injection significantly reduced the hematoma volume, lesion volume, and perihematomal neutrophil infiltration. Hematoma aspiration plus subsequent intralesional injection is simple, feasible, and safe. This ICH model can be used to assess the effectiveness of hematoma removal plus local delivery of chemicals.
血肿抽吸联合局部化学药物递送可能比脑出血（ICH）中的任何单一治疗更有效。本研究旨在建立一种 ICH 后血肿抽吸加瘤内注射的大鼠模型。ICH 通过纹状体内注射细菌胶原酶 IV 在成年 Sprague-Dawley 大鼠中诱导。ICH 后 3.5 小时进行血肿抽吸。抽吸后，将生理盐水注入病变腔。血肿抽吸加或不加随后的盐水注射均可显著减少血肿体积、病变体积和血肿周围中性粒细胞浸润。血肿抽吸加随后的瘤内注射简单、可行且安全。这种 ICH 模型可用于评估血肿清除加局部化学药物递送的效果。
