• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Enhanced Neuroprotection of Minimally Invasive Surgery Joint Local Cooling Lavage against ICH-induced Inflammation Injury and Apoptosis in Rats.微创手术联合局部降温灌洗对大鼠脑出血诱导的炎症损伤和细胞凋亡的增强神经保护作用。
Cell Mol Neurobiol. 2016 Jul;36(5):647-55. doi: 10.1007/s10571-015-0245-z. Epub 2015 Jul 31.
2
Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury.褪黑素通过抑制细胞凋亡、炎症、氧化应激、DNA 损伤和线粒体损伤缓解大鼠脑出血后二次脑损伤。
Transl Stroke Res. 2018 Feb;9(1):74-91. doi: 10.1007/s12975-017-0559-x. Epub 2017 Aug 1.
3
Therapeutic time window and regulation of autophagy by mild hypothermia after intracerebral hemorrhage in rats.大鼠脑出血后治疗时间窗及亚低温对自噬的调控
Brain Res. 2018 Jul 1;1690:12-22. doi: 10.1016/j.brainres.2018.04.005. Epub 2018 Apr 9.
4
Baihui-Penetrating-Qubin Acupuncture Attenuates Neurological Deficits Through SIRT1/FOXO1 Reducing Oxidative Stress and Neuronal Apoptosis in Intracerebral Hemorrhage Rats.百会透曲鬓针刺通过SIRT1/FOXO1减轻脑出血大鼠氧化应激和神经元凋亡从而改善神经功能缺损
Brain Behav. 2024 Dec;14(12):e70095. doi: 10.1002/brb3.70095.
5
Gastrodin Attenuates Neuronal Apoptosis and Neurological Deficits after Experimental Intracerebral Hemorrhage.天麻素减轻实验性脑出血后神经元凋亡和神经功能缺损。
J Stroke Cerebrovasc Dis. 2020 Jan;29(1):104483. doi: 10.1016/j.jstrokecerebrovasdis.2019.104483. Epub 2019 Nov 11.
6
Alpha-asarone ameliorates neurological deterioration of intracerebral hemorrhagic rats by alleviating secondary brain injury via anti-excitotoxicity pathways.α-细辛脑通过抗兴奋毒性途径减轻脑出血大鼠的继发性脑损伤，从而改善神经功能恶化。
Phytomedicine. 2022 Oct;105:154363. doi: 10.1016/j.phymed.2022.154363. Epub 2022 Jul 28.
7
Early-stage minimally invasive procedures decrease perihematomal endothelin-1 levels and improve neurological functioning in a rabbit model of intracerebral hemorrhage.早期微创操作可降低脑出血兔模型中血肿周围内皮素-1水平并改善神经功能。
Neurol Res. 2015 Apr;37(4):320-7. doi: 10.1179/1743132814Y.0000000446. Epub 2014 Sep 25.
8
Baicalein Promotes Neuronal and Behavioral Recovery After Intracerebral Hemorrhage Via Suppressing Apoptosis, Oxidative Stress and Neuroinflammation.黄芩苷通过抑制细胞凋亡、氧化应激和神经炎症促进脑出血后的神经元和行为恢复。
Neurochem Res. 2017 May;42(5):1345-1353. doi: 10.1007/s11064-017-2179-y. Epub 2017 Jan 21.
9
Effect of delayed mild brain hypothermia on edema formation after intracerebral hemorrhage in rats.延迟性轻度脑低温对大鼠脑出血后水肿形成的影响。
J Stroke Cerebrovasc Dis. 2008 Jul-Aug;17(4):187-95. doi: 10.1016/j.jstrokecerebrovasdis.2008.01.003.
10
Early Combined Therapy with Pharmacologically Induced Hypothermia and Edaravone Exerts Neuroprotective Effects in a Rat Model of Intracerebral Hemorrhage.早期联合应用药物性低温和依达拉奉治疗对脑出血大鼠模型具有神经保护作用。
Cell Biochem Biophys. 2015 Nov;73(2):581-587. doi: 10.1007/s12013-015-0584-x.

引用本文的文献

1
Celastrol Ameliorates Neuronal Mitochondrial Dysfunction Induced by Intracerebral Hemorrhage via Targeting cAMP-Activated Exchange Protein-1.藜芦碱通过靶向 cAMP 激活交换蛋白 1 改善脑出血引起的神经元线粒体功能障碍。
Adv Sci (Weinh). 2024 May;11(19):e2307556. doi: 10.1002/advs.202307556. Epub 2024 Mar 14.
2
Secondary Brain Injury by Oxidative Stress After Cerebral Hemorrhage: Recent Advances.脑出血后氧化应激所致的继发性脑损伤：最新进展
Front Cell Neurosci. 2022 Jun 23;16:853589. doi: 10.3389/fncel.2022.853589. eCollection 2022.
3
Development and Clinical Validation of a Finite Element Method Model Mapping Focal Intracranial Cooling.开发并临床验证一种用于映射颅内焦点冷却的有限元方法模型。
IEEE Trans Neural Syst Rehabil Eng. 2022;30:2168-2174. doi: 10.1109/TNSRE.2022.3161085. Epub 2022 Aug 11.
4
Glymphatic Drainage Blocking Aggravates Brain Edema, Neuroinflammation Modulating TNF-α, IL-10, and AQP4 After Intracerebral Hemorrhage in Rats.淋巴系统引流阻断加重大鼠脑出血后脑水肿及神经炎症，调节肿瘤坏死因子-α、白细胞介素-10和水通道蛋白4
Front Cell Neurosci. 2021 Dec 17;15:784154. doi: 10.3389/fncel.2021.784154. eCollection 2021.
5
lncRNA MEG3 Downregulation Relieves Intracerebral Hemorrhage by Inhibiting Oxidative Stress and Inflammation in an miR-181b-Dependent Manner.长链非编码 RNA MEG3 通过抑制 miR-181b 依赖的氧化应激和炎症缓解脑出血。
Med Sci Monit. 2021 Jul 16;27:e929435. doi: 10.12659/MSM.929435.
6
Inhibition of NOX4/ROS Suppresses Neuronal and Blood-Brain Barrier Injury by Attenuating Oxidative Stress After Intracerebral Hemorrhage.抑制NOX4/ROS通过减轻脑出血后的氧化应激来抑制神经元和血脑屏障损伤。
Front Cell Neurosci. 2020 Nov 13;14:578060. doi: 10.3389/fncel.2020.578060. eCollection 2020.
7
A Multi-Model Pipeline for Translational Intracerebral Haemorrhage Research.用于转化性脑出血研究的多模型管道。
Transl Stroke Res. 2020 Dec;11(6):1229-1242. doi: 10.1007/s12975-020-00830-z. Epub 2020 Jul 7.
8
Examining potential side effects of therapeutic hypothermia in experimental intracerebral hemorrhage.研究治疗性低温对实验性脑出血的潜在副作用。
J Cereb Blood Flow Metab. 2017 Aug;37(8):2975-2986. doi: 10.1177/0271678X16681312. Epub 2016 Jan 1.
9
Carnosine Attenuates Brain Oxidative Stress and Apoptosis After Intracerebral Hemorrhage in Rats.肌肽减轻大鼠脑出血后的脑氧化应激和细胞凋亡
Neurochem Res. 2017 Feb;42(2):541-551. doi: 10.1007/s11064-016-2104-9. Epub 2016 Nov 21.
10
Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets.脑出血中的氧化应激：来源、机制及治疗靶点
Oxid Med Cell Longev. 2016;2016:3215391. doi: 10.1155/2016/3215391. Epub 2015 Dec 30.

本文引用的文献

1
Effects of selective hypothermia on blood-brain barrier integrity and tight junction protein expression levels after intracerebral hemorrhage in rats.选择性低温对脑出血后血脑屏障完整性和紧密连接蛋白表达水平的影响。
Biol Chem. 2013 Oct;394(10):1317-24. doi: 10.1515/hsz-2013-0142.
2
Transient receptor potential canonical 3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice.瞬时受体电位经典型 3 抑制剂 Pyr3 可改善小鼠脑出血后的预后并减轻星形胶质细胞增生。
Stroke. 2013 Jul;44(7):1981-7. doi: 10.1161/STROKEAHA.113.679332. Epub 2013 May 14.
3
Rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection.允许血肿抽吸加腔内注射的脑出血大鼠模型。
Exp Anim. 2013;62(1):63-9. doi: 10.1538/expanim.62.63.
4
Neuroprotective effects of focal brain cooling on photochemically-induced cerebral infarction in rats: analysis from a neurophysiological perspective.从神经生理学角度分析局部脑冷却对光化学诱导的大鼠脑梗死的神经保护作用。
Brain Res. 2013 Feb 25;1497:53-60. doi: 10.1016/j.brainres.2012.11.041. Epub 2012 Dec 23.
5
Neuroprotective effect of atorvastatin involves suppression of TNF-α and upregulation of IL-10 in a rat model of intracerebral hemorrhage.阿托伐他汀通过抑制 TNF-α 和上调 IL-10 发挥对脑出血大鼠的神经保护作用。
Cell Biochem Biophys. 2013 Jun;66(2):337-46. doi: 10.1007/s12013-012-9453-z.
6
Treadmill rehabilitation treatment enhanced BDNF-TrkB but not NGF-TrkA signaling in a mouse intracerebral hemorrhage model.跑步机康复治疗增强了小鼠脑出血模型中的 BDNF-TrkB 但不影响 NGF-TrkA 信号。
Neurosci Lett. 2012 Oct 31;529(1):28-32. doi: 10.1016/j.neulet.2012.09.021. Epub 2012 Sep 19.
7
Minimally invasive surgery for spontaneous supratentorial intracerebral hemorrhage: a meta-analysis of randomized controlled trials.自发性幕上脑出血的微创外科治疗：随机对照试验的荟萃分析。
Stroke. 2012 Nov;43(11):2923-30. doi: 10.1161/STROKEAHA.112.667535. Epub 2012 Sep 18.
8
Statin use and microbleeds in patients with spontaneous intracerebral hemorrhage.他汀类药物的使用与自发性脑出血患者的微出血。
Stroke. 2012 Oct;43(10):2677-81. doi: 10.1161/STROKEAHA.112.657486. Epub 2012 Jul 24.
9
Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage-induced secondary brain injury and as potential targets for intervention.凝血酶和血红素作为脑出血继发性脑损伤机制中的核心因素，以及作为潜在干预靶点。
Neurosurg Focus. 2012 Apr;32(4):E8. doi: 10.3171/2012.1.FOCUS11366.
10
Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage.血红素通过 TLR4 介导的 MyD88/TRIF 信号通路在脑出血中引起炎症损伤。
J Neuroinflammation. 2012 Mar 6;9:46. doi: 10.1186/1742-2094-9-46.

微创手术联合局部降温灌洗对大鼠脑出血诱导的炎症损伤和细胞凋亡的增强神经保护作用。

Enhanced Neuroprotection of Minimally Invasive Surgery Joint Local Cooling Lavage against ICH-induced Inflammation Injury and Apoptosis in Rats.

作者信息

Liu Xi-Chang, Jing Li-Yan, Yang Ming-Feng, Wang Kun, Wang Yuan, Fu Xiao-Yan, Fang Jie, Hou Ya-Jun, Sun Jing-Yi, Li Da-Wei, Zhang Zong-Yong, Mao Lei-Lei, Tang You-Mei, Fu Xiao-Ting, Fan Cun-Dong, Yang Xiao-Yi, Sun Bao-Liang

机构信息

Department of Neurology, Shandong University School of Medicine, Jinan, 250012, Shandong, China.

Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, 271000, Shandong, China.

出版信息

Cell Mol Neurobiol. 2016 Jul;36(5):647-55. doi: 10.1007/s10571-015-0245-z. Epub 2015 Jul 31.

DOI:10.1007/s10571-015-0245-z
PMID:26224360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11482297/
Abstract

Hypothermia treatment is one of the neuroprotective strategies that improve neurological outcomes effectively after brain damage. Minimally invasive surgery (MIS) has been an important treatment of intracerebral hemorrhage (ICH). Herein, we evaluated the neuroprotective effect and mechanism of MIS joint local cooling lavage (LCL) treatment on ICH via detecting the inflammatory responses, oxidative injury, and neuronal apoptosis around the hematoma cavity in rats. ICH model was established by type IV collagenase caudatum infusion. The rats were treated with MIS 6 h after injection, and then were lavaged by normothermic (37 °C) and hypothermic (33 °C) normal saline in brain separately. The results indicated that MIS joint LCL treatment showed enhanced therapeutic effects against ICH-induced inflammation injury and apoptosis in rats, as convinced by the decline of TUNEL-positive cells, followed by the decrease of IL-1β and LDH and increase of IL-10 and SOD. This study demonstrated that the strategy of using MIS joint LCL may achieve enhanced neuroprotection against ICH-induced inflammation injury and apoptosis in rats with potential clinic application.

摘要

亚低温治疗是脑损伤后有效改善神经功能结局的神经保护策略之一。微创手术（MIS）一直是脑出血（ICH）的重要治疗方法。在此，我们通过检测大鼠血肿腔周围的炎症反应、氧化损伤和神经元凋亡，评估了MIS联合局部低温灌洗（LCL）治疗ICH的神经保护作用及其机制。通过向尾状核注射IV型胶原酶建立ICH模型。注射后6小时对大鼠进行MIS治疗，然后分别用常温（37°C）和低温（33°C）生理盐水对脑部进行灌洗。结果表明，MIS联合LCL治疗对ICH诱导的大鼠炎症损伤和凋亡具有增强的治疗效果，这可通过TUNEL阳性细胞数量的减少得到证实，随后IL-1β和LDH减少，IL-10和SOD增加。本研究表明，MIS联合LCL策略可能对ICH诱导的大鼠炎症损伤和凋亡具有增强的神经保护作用，具有潜在的临床应用价值。