Boston, Mass. From the Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, and the Department of Dermatology, Brigham and Women's Hospital.
Plast Reconstr Surg. 2013 Feb;131(2):216-223. doi: 10.1097/PRS.0b013e3182789afa.
The most commonly performed skin rejuvenation procedure, laser resurfacing, is associated with adverse events and significant expense. The authors have developed a novel device that uses micro-coring needles to remove tissue in a fractional pattern and avoid the side effects of laser therapy. The authors compare the efficacy of these needles to standard needles in a pig model.
One swine was treated with three needle types: standard hypodermic, solid hypodermic, and the authors' novel coring needles. Thirty-two 1 × 1-inch sites per flank received either 20 or 40 percent treatment coverage. Photographs were taken and punch biopsies were performed at days 0, 7, 28, 56, and 84. Biopsy specimens were evaluated for histology and collagen content.
All treatment sites healed quickly, with no evidence of scarring or infection. Coring sites were easily identified and contained increased fibroblast activity and newly synthesized collagen. At 1 month, the papillary dermis and epidermis of the coring sites were up to 196 percent thicker compared with controls (p < 0.001). The coring sites had enhanced undulating rete ridges-consistent with regeneration. At 3 months, a pronounced increase in collagen fibers and newly organized and augmented elastic fibers was seen. Enzyme-linked immunosorbent assay confirmed an 89 percent increase in collagen content in these coring sites (p < 0.001).
This novel approach to skin rejuvenation was found to effectively induce the microscopic and biological endpoints of skin rejuvenation. This may provide a new modality for the safe and cost-effective treatment of age-related rhytides, skin laxity, photodamage, scarring, and striae.
最常进行的皮肤年轻化程序是激光换肤术，但它与不良反应和高昂费用有关。作者开发了一种新设备，该设备使用微芯针以分数图案去除组织，避免激光治疗的副作用。作者在猪模型中比较了这些针与标准针的效果。
一只猪的两侧各用三种针型处理 32 个 1×1 英寸的部位：标准皮下、实心皮下和作者的新型芯针。每个部位接受 20%或 40%的治疗覆盖率。在第 0、7、28、56 和 84 天拍摄照片并进行皮肤活检。对活检标本进行组织学和胶原蛋白含量评估。
所有治疗部位均迅速愈合，无疤痕或感染的证据。芯针部位很容易识别，且含有增加的成纤维细胞活性和新合成的胶原蛋白。在 1 个月时，芯针部位的乳头真皮和表皮比对照组厚达 196%（p<0.001）。芯针部位的起伏状真皮嵴更明显——与再生一致。在 3 个月时，观察到胶原纤维和新组织化的、增强的弹性纤维明显增加。酶联免疫吸附试验证实这些芯针部位的胶原蛋白含量增加了 89%（p<0.001）。
这种新的皮肤年轻化方法被发现可有效诱导皮肤年轻化的微观和生物学终点。这可能为安全、经济有效的治疗与年龄相关的皱纹、皮肤松弛、光损伤、疤痕和妊娠纹提供新的手段。
