Department of Mechanical Engineering, University of Alberta, Edmonton, AB, T6G2G8, Canada.
Ann Biomed Eng. 2013 May;41(5):979-89. doi: 10.1007/s10439-013-0747-0. Epub 2013 Jan 29.
Deposition of particles in the aerodynamic diameter range of 0.5-6.7 μm was measured in nine replicas of the extrathoracic airways of adults with four sinusoidal patterns and oral breathing. The four chosen breathing patterns are typical of those occurring during natural resting breathing and during nebulization therapy. Additionally, deposition of micrometer-sized particles in the "Alberta Idealized Adult Throat," which was previously found useful in simulating the average deposition of particles during inhalation of constant flow rates, was measured during inhalation of the four sinusoidal patterns in this study. To reduce intersubject scatter in developing predictive correlations, the non-dimensional Reynolds (Re) and Stokes (Stk) numbers are used with the square root of the average cross sectional area of the oral airways as the characteristic diameter being found to reduce intersubject variability to the highest extent. Our best fit to the deposition data is given by η = [1 - 1/(1.51 x 10(5)(Stk(3.03)Re(0.25)) + 1)] x 100. Moreover, the "Alberta Idealized Adult Throat" is found to mimic average deposition, given in past in vivo studies, in the upper airways of adults during natural tidal breathing.
在 9 个成年人的胸外气道模型中，以 4 种正弦波呼吸模式和口呼吸方式测量了 0.5-6.7μm 空气动力学直径范围内的颗粒沉积。选择的 4 种呼吸模式是自然休息呼吸和雾化治疗过程中常见的呼吸模式。此外，在本研究中，还测量了在吸入这 4 种正弦波呼吸模式时，先前在模拟吸入恒流时平均颗粒沉积中发现有用的“阿尔伯塔理想成人咽喉”中微米级颗粒的沉积。为了减少预测相关性中的个体间差异，使用无量纲雷诺数（Re）和斯托克斯数（Stk）以及口腔气道的平均横截面积的平方根作为特征直径，发现这可以最大限度地减少个体间的差异。我们对沉积数据的最佳拟合是 η = [1 - 1/(1.51 x 10(5)(Stk(3.03)Re(0.25)) + 1)] x 100。此外，发现“阿尔伯塔理想成人咽喉”在模拟自然潮汐呼吸过程中成人上呼吸道的平均沉积方面与过去的体内研究结果相似。
