Department of Otolaryngology, Department of Electrical Engineering, and Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA 98195, USA.
IEEE Trans Biomed Eng. 2013 Jun;60(6):1685-92. doi: 10.1109/TBME.2013.2241433. Epub 2013 Jan 21.
A vestibular neural prosthesis was designed on the basis of a cochlear implant for treatment of Meniere's disease and other vestibular disorders. Computer control software was developed to generate patterned pulse stimuli for exploring optimal parameters to activate the vestibular nerve. Two rhesus monkeys were implanted with the prototype vestibular prosthesis and they were behaviorally evaluated post implantation surgery. Horizontal and vertical eye movement responses to patterned electrical pulse stimulations were collected on both monkeys. Pulse amplitude modulated (PAM) and pulse rate modulated (PRM) trains were applied to the lateral canal of each implanted animal. Robust slow-phase nystagmus responses following the PAM or PRM modulation pattern were observed in both implanted monkeys in the direction consistent with the activation of the implanted canal. Both PAM and PRM pulse trains can elicit a significant amount of in-phase modulated eye velocity changes and they could potentially be used for efficiently coding head rotational signals in future vestibular neural prostheses.
基于人工耳蜗，设计了一种前庭神经假体，用于治疗梅尼埃病和其他前庭疾病。开发了计算机控制软件，以产生模式脉冲刺激，探索激活前庭神经的最佳参数。两只恒河猴被植入了这种原型前庭神经假体，并在术后进行了行为评估。对两只猴子的水平和垂直眼动对模式电脉冲刺激的反应进行了收集。对每个植入动物的外侧半规管施加了调幅脉冲（PAM）和调制率脉冲（PRM）。在与植入管激活方向一致的情况下，在两只植入猴中均观察到了 PAM 或 PRM 调制模式后的稳健慢相眼球震颤反应。PAM 和 PRM 脉冲序列均可引起显著的同相调制眼球速度变化，它们可能在未来的前庭神经假体中用于有效地编码头部旋转信号。
