LSIS Lab, UMR CNRS 7296, Aix-Marseille Université and CNRS, 13288 Marseille Cedex 09, France.
IEEE Trans Med Imaging. 2013 May;32(5):873-87. doi: 10.1109/TMI.2013.2241651. Epub 2013 Jan 21.
In the context of inter subject brain surface matching, we present a parameterization of the cortical surface constrained by a model of cortical organization. The parameterization is defined via an harmonic mapping of each hemisphere surface to a rectangular planar domain that integrates a representation of the model. As opposed to previous landmark-based registration methods we do not match folds between individuals but instead optimize the fit between cortical sulci and specific iso-coordinate axis in the model. This strategy overcomes some limitation to sulcus-based registration techniques such as topological variability in sulcal landmarks across subjects. Experiments on 62 subjects with manually traced sulci are presented and compared with the result of the Freesurfer software. The evaluation involves a measure of dispersion of sulci with both angular and area distortions. We show that the model-based strategy can lead to a natural, efficient and very fast (less than 5 min per hemisphere) method for defining inter subjects correspondences. We discuss how this approach also reduces the problems inherent to anatomically defined landmarks and open the way to the investigation of cortical organization through the notion of orientation and alignment of structures across the cortex.
在跨被试脑表面匹配的背景下，我们提出了一种受皮质组织模型约束的皮质表面参数化方法。该参数化通过对每个半球表面进行调和映射到一个矩形平面域来定义，该平面域集成了模型的表示。与以前基于地标点的配准方法不同，我们不是匹配个体之间的褶皱，而是优化皮质沟和模型中特定等坐标轴之间的拟合。这种策略克服了基于沟回的配准技术的一些限制，例如在不同个体之间的沟回地标点的拓扑可变性。我们对 62 名手动追踪沟回的受试者进行了实验，并将结果与 Freesurfer 软件的结果进行了比较。该评估涉及到对沟回的离散度进行测量，包括角度和面积的扭曲。我们表明，基于模型的策略可以为定义跨被试对应关系提供一种自然、高效且非常快速（每侧半球不到 5 分钟）的方法。我们还讨论了这种方法如何减少基于解剖定义的地标点所固有的问题，并为通过皮质表面结构的定向和对齐的概念来研究皮质组织开辟了道路。
