Lucas Aimee L, Chang Michelle M, Lipsyc Marla D, Frucht Harold
Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Methods Mol Biol. 2013;980:205-14. doi: 10.1007/978-1-62703-287-2_10.
Pancreatic cancer (PC) is typically a fatal disease due to its rapid growth and the lack of early diagnostic -techniques. Because approximately 10% of PCs are attributable to a hereditary susceptibility, identifying and studying patients with a family history of PC or known genetic predisposition to PC can improve the prevention, diagnosis, and treatment of PC. A skilled team of study investigators, physicians, genetic counselors, and data managers must work with patients and families to confidentially store and organize data from PC patients and high-risk patients. This data, collected in conjunction with patients' tissue and blood specimens, will contribute to the understanding of the biology, etiology, and epidemiology of PC, and can ultimately improve screening and management for patients with an underlying hereditary predisposition to PC.
胰腺癌（PC）通常是一种致命疾病，因其生长迅速且缺乏早期诊断技术。由于约10%的胰腺癌归因于遗传易感性，识别和研究有胰腺癌家族史或已知胰腺癌遗传易感性的患者可改善胰腺癌的预防、诊断和治疗。一支由研究调查人员、医生、遗传咨询师和数据管理人员组成的专业团队必须与患者及其家属合作，以保密的方式存储和整理来自胰腺癌患者和高危患者的数据。这些与患者的组织和血液样本一起收集的数据，将有助于了解胰腺癌的生物学、病因学和流行病学，并最终改善对有潜在胰腺癌遗传易感性患者的筛查和管理。
