Department of Environmental & Occupational Medicine, National Research Centre, Cairo, Egypt.
Am J Ind Med. 2013 Jul;56(7):818-24. doi: 10.1002/ajim.22162. Epub 2013 Jan 28.
In a study of textile workers, the effects of occupational exposure to cotton dust-with possible exposure to aflatoxin-on levels of some liver tumor biomarkers were explored.
The study included 58 textile workers and 64 controls. Skin prick tests, urinary Aflatoxin M1 (AFM1) and the tumor biomarkers (alpha-fetoprotein (AFP), alpha-L-fucosidase (AFU), insulin-like growth factors (IGF-1) were measured.
Positive reactants to Aspergillus niger, Aspergillus flavus, and cotton dust were significantly higher in pre-spinning (14.3%, 28.6%, and 28.6%, respectively) and spinning workers (25.0%, 33.3%, and 25.0%, respectively) compared to controls (4.7%, 7.8%, and 3.1%, respectively). Urinary AFM1 was significantly higher in the pre-spinning, spinning, and weaving groups compared to controls (554.2 ± 346.2 pg/ml, 459.1 ± 781.6 pg/ml, 296.5 ± 336.5 pg/ml and 68.5 ± 136.8 pg/ml, respectively). We found a highly significant increase in levels of serum AFU in textile workers, compared to the control group.
Exposure to fungi had a significant effect on AFM1 measurements and tumor biomarkers, especially in allergic textile workers (with the exception of the arginase biomarker), though results were generally within normal limits.
在一项针对纺织工人的研究中，探讨了职业暴露于棉花粉尘（可能接触黄曲霉毒素）对某些肝肿瘤生物标志物水平的影响。
本研究纳入了 58 名纺织工人和 64 名对照者。进行了皮肤点刺试验、尿黄曲霉 M1（AFM1）和肿瘤生物标志物（甲胎蛋白（AFP）、α-L-岩藻糖苷酶（AFU）、胰岛素样生长因子（IGF-1）的检测。
与对照组（分别为 4.7%、7.8%和 3.1%）相比，前纺（分别为 14.3%、28.6%和 28.6%）和纺丝工人（分别为 25.0%、33.3%和 25.0%）对黑曲霉、黄曲霉和棉花粉尘的阳性反应物明显更高。与对照组相比，前纺、纺丝和织造组的尿 AFM1 明显升高（分别为 554.2±346.2pg/ml、459.1±781.6pg/ml、296.5±336.5pg/ml 和 68.5±136.8pg/ml）。与对照组相比，我们发现纺织工人血清 AFU 水平显著升高。
暴露于真菌对 AFM1 测量和肿瘤生物标志物有显著影响，尤其是在过敏的纺织工人中（除了精氨酸酶生物标志物外），尽管结果通常在正常范围内。
