Prakash A O, Mathur A, Mehta H, Mathur R
School of Studies in Zoology, Jiwaji University, Gwalior, India.
J Ethnopharmacol. 1990 Mar;28(3):337-47. doi: 10.1016/0378-8741(90)90085-8.
The effect of 50% ethanol and benzene extracts of Hibiscus rosa sinensis flowers was studied on the concentration of Na+ and K+ in the serum and uterine flushings of ovariectomized, mated and cyclic rats. In ovariectomized rats, both extracts given alone did not alter the K+ content of the uterine flushings but when administered with estradiol dipropionate (EDP), a partial antagonism was observed when compared to EDP given alone. Conjoint treatment of extracts with EDP plus progesterone did not induce any significant change. In mated rats, both extracts did not alter the concentration of Na+ on the day of implantation but decreased significantly the concentration of K+ in uterine fluid. In cyclic rats, the administration of the extracts for 6 and 12 days did not cause any significant change in the concentration of K+ of uterine flushings but their administration for 18 days caused a significant decrease. In all three experiments, the concentration of Na+ in uterine flushings and of Na+ and K+ of serum did not show any significant changes.
研究了扶桑花50%乙醇提取物和苯提取物对去卵巢、交配及正常发情大鼠血清和子宫冲洗液中Na⁺和K⁺浓度的影响。在去卵巢大鼠中，单独给予两种提取物均未改变子宫冲洗液中的K⁺含量，但与单独给予二丙酸雌二醇（EDP）相比，与EDP联合给药时观察到部分拮抗作用。提取物与EDP加孕酮联合处理未引起任何显著变化。在交配大鼠中，两种提取物在植入当天均未改变Na⁺浓度，但显著降低了子宫液中K⁺的浓度。在正常发情大鼠中，提取物给药6天和12天未引起子宫冲洗液中K⁺浓度的任何显著变化，但给药18天则导致显著降低。在所有三个实验中，子宫冲洗液中的Na⁺浓度以及血清中的Na⁺和K⁺浓度均未显示任何显著变化。
