Wayne State University School of Medicine, Detroit, MI, USA.
J Pediatr Psychol. 2013 Jul;38(6):638-48. doi: 10.1093/jpepsy/jss132. Epub 2013 Jan 28.
To pilot test a two-session computer-delivered motivational intervention to facilitate adherence among youth with HIV newly prescribed antiretroviral treatment (ART).
Youth (N = 76) newly prescribed ART were recruited from 8 sites, and were randomized to the intervention or an active nutrition and physical activity control. Primary outcomes were HIV-1 viral load at baseline, 3 months, and 6 months, and self-reported adherence at 3 and 6 months.
Satisfaction ratings were high. Effect sizes suggested that the intervention group showed a greater drop than controls in viral load from baseline to 6 months (Cohen's d = 0.39 at 3 months; d = 0.19 at 6 months), and had greater percent undetectable by 6 months (d = 0.28). Effects sizes were medium to large for 7-day and weekend adherence.
A brief computer-delivered motivational intervention showed promise for youth starting ART and is ready to be tested in a full-scale clinical trial.
试点测试两阶段计算机传递动机干预措施，以促进新接受抗逆转录病毒治疗（ART）的青少年坚持治疗。
从 8 个地点招募了新接受 ART 的青少年（N=76），并将他们随机分配到干预组或积极的营养和身体活动对照组。主要结果是基线、3 个月和 6 个月时的 HIV-1 病毒载量，以及 3 个月和 6 个月时的自我报告的依从性。
满意度评分很高。效果大小表明，与对照组相比，干预组的病毒载量从基线到 6 个月的下降更大（3 个月时 Cohen's d = 0.39；6 个月时 d = 0.19），并且在 6 个月时达到不可检测的比例更高（d = 0.28）。7 天和周末的依从性的效果大小为中等到大。
简短的计算机传递动机干预措施为开始接受 ART 的青少年提供了希望，并且已经准备好进行全面的临床试验。
