Digestive System Research Unit, University Hospital Vall d'Hebron, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Neurogastroenterol Motil. 2013 Apr;25(4):339-e253. doi: 10.1111/nmo.12068. Epub 2013 Jan 29.
Using an experimental model of colonic gas infusion, we previously showed that the abdominal walls adapt to its content by an active phenomenon of abdominal accommodation. We now hypothesized that abdominal accommodation is a physiological phenomenon, and aimed to confirm that it can be induced by ingestion of a meal; a secondary aim was to determine whether the response to gut filling is region-specific.
In healthy subjects (n = 24) a nutrient test meal was administered until tolerated at a rate of 50 mL min(-1). Electromyographic (EMG) activity of the anterior wall (upper and lower rectus, external and internal oblique) was measured via four pairs of surface electrodes, and EMG activity of the diaphragm via intraluminal electrodes on an esophageal tube. To address the secondary aim, the response to gastric filling was compared with that induced by colonic filling (1440 mL 30 min(-1) anal gas infusion; n = 8).
Participants tolerated 927 ± 66 mL of meal (450-1500 mL). Meal ingestion induced progressive diaphragmatic relaxation (EMG reduction by 16 ± 2%; P < 0.01) and selective contraction of the upper abdominal wall (24 ± 2% increase in activity of the upper rectus and external oblique; P < 0.01 for both), with no significant changes in the lower rectus (4 ± 2%) or internal oblique (5 ± 3%). Colonic gas infusion induced a similar response, but with an overall contraction of the anterior wall.
CONCLUSIONS & INFERENCES: Meal ingestion induces a metered and region-specific response of the abdominal walls to accommodate the volume load. Abnormal abdominal accommodation could be involved in postprandial bloating.
我们之前使用结肠气体输注的实验模型表明，腹部通过一种主动的腹部顺应现象来适应其内容物。我们现在假设腹部顺应是一种生理现象，并旨在证实它可以通过摄入食物来诱导；次要目标是确定对肠道充盈的反应是否具有区域特异性。
在健康受试者（n = 24）中，以 50 毫升/分钟的速度给予营养测试餐，直到耐受为止。通过四个表面电极测量前壁（上、下直肌、外斜肌和内斜肌）的肌电图（EMG）活动，并通过食管管内的电极测量膈肌的 EMG 活动。为了解决次要目标，比较了胃充盈和结肠充盈引起的反应（1440 毫升 30 分钟-1肛门气体输注；n = 8）。
参与者耐受了 927 ± 66 毫升的餐食（450-1500 毫升）。进餐诱导膈肌逐渐松弛（EMG 减少 16 ± 2%；P < 0.01）和上腹部壁的选择性收缩（上直肌和外斜肌的活动增加 24 ± 2%；两者均 P < 0.01），下直肌（4 ± 2%）或内斜肌（5 ± 3%）无明显变化。结肠气体输注引起类似的反应，但前壁整体收缩。
进餐引起腹部壁对容量负荷的计量和区域特异性反应。餐后腹胀可能与腹部顺应异常有关。
