Department of General Practice, KU Leuven, Leuven, Belgium.
Age Ageing. 2013 Mar;42(2):186-90. doi: 10.1093/ageing/afs186. Epub 2013 Jan 29.
vitamin D deficiency is a well-known cause of bone loss and fractures but its association, especially among the oldest old, with muscle weakness is less obvious.
to investigate the relationship between 25-hydroxyvitamin D (25-OHD) and muscle performance in persons aged 80 years and older.
baseline results of the Belfrail study, a prospective, population-based cohort study were used to study balance, grip strength and gait speed in relation to 25-OHD serum levels in 367 subjects.
a sufficient 25-OHD serum level of 30 ng/ml or more was found in 12.8% of the population. The prevalence of vitamin deficiency (20-29 ng/ml), insufficiency (10-19 ng/ml) and severe insufficiency (<10 ng/ml) was 21.5, 33 and 32.7%, respectively. No significant relation between balance, gait speed and grip strength, and serum 25-OHD was detected neither in bivariate analysis nor after adjustment for age, gender, level of education, institutionalisation, smoking status, body mass index, co-morbidity, level of activity, season, CRP, renal function, serum calcium parathyroid hormone levels, vitamin D intake and use of loop or thiazide diuretics.
in this cohort of octogenarians vitamin D deficiency was highly prevalent. We could not confirm the findings of previous studies showing an association between serum 25-OHD and physical performance in elderly.
维生素 D 缺乏是众所周知的导致骨质流失和骨折的原因，但它与肌肉无力的关系，尤其是在最年长的老年人中，并不明显。
研究 80 岁及以上人群 25-羟维生素 D（25-OHD）与肌肉功能之间的关系。
使用 Belfrail 研究的基线结果，一项前瞻性、基于人群的队列研究，研究了 367 名受试者的 25-OHD 血清水平与平衡、握力和步速之间的关系。
发现人群中有 12.8%的人血清 25-OHD 水平达到足够的 30ng/ml 或更高。维生素缺乏症（20-29ng/ml）、不足症（10-19ng/ml）和严重不足症（<10ng/ml）的患病率分别为 21.5%、33%和 32.7%。在双变量分析和调整年龄、性别、教育水平、机构化、吸烟状况、体重指数、合并症、活动水平、季节、C 反应蛋白、肾功能、血清钙甲状旁腺激素水平、维生素 D 摄入量和使用环或噻嗪类利尿剂后，均未发现平衡、步速和握力与血清 25-OHD 之间存在显著关系。
在这个 80 岁以上的队列中，维生素 D 缺乏症的患病率很高。我们无法证实先前研究的发现，即血清 25-OHD 与老年人的身体机能之间存在关联。
