日本中老年男性和女性血清25-羟基维生素D与身体机能指标之间的关联：云仙研究
Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study.
作者信息
Uchiyama Michiko, Mizukami Satoshi, Arima Kazuhiko, Nishimura Takayuki, Tomita Yoshihito, Abe Yasuyo, Tanaka Natsumi, Honda Yuzo, Goto Hisashi, Hasegawa Maiko, Sou Youko, Tsujimoto Ritsu, Kanagae Mitsuo, Osaki Makoto, Aoyagi Kiyoshi
机构信息
Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Leading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
出版信息
PLoS One. 2021 Dec 23;16(12):e0261639. doi: 10.1371/journal.pone.0261639. eCollection 2021.
PURPOSE
Regarding epidemiological studies, the role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly people is still controversial. The purpose of the present study was to investigate the associations between 25-hydroxyvitamin D [25(OH)D] and physical performance among community-dwelling middle-aged and old Japanese men and women.
METHODS
The subjects were community-dwelling 297 men and 415 women aged 50 years and over. Data on height (m) and weight (kg) were collected. Serum 25(OH)D, parathyroid hormone, calcium, and albumin levels were measured. Serum 25(OH)D was classified into deficiency group: < 20 ng/mL, insufficiency group: 20-30 ng/mL, and sufficiency group: ≧ 30 ng/mL. Physical performance was assessed by grip strength, chair stand time, and functional reach. Information on current smoking, alcohol drinking, regular exercise, any comorbidities (hypertension, heart disease, diabetes mellitus, lung disease, and stroke), and pain (lumbar and knee) was collected.
RESULTS
Vitamin D deficiency and insufficiency based on serum 25(OH)D levels were observed in 15.2% and 56.9% of men and 52.0% and 43.6% of women, respectively. In men, higher serum 25(OH)D levels were associated with better grip strength (p for trend = 0.003), chair stand time (p for trend = 0.042), and functional reach (p for trend <0.001). On the other hand, these parameters were not associated with serum 25(OH)D levels in women.
CONCLUSION
A higher level of serum 25(OH)D was associated with better physical performance in men but not in women.
目的
在流行病学研究中，维生素D在老年人肌肉骨骼功能（肌肉无力和身体机能）方面的作用仍存在争议。本研究的目的是调查社区居住的日本中老年人血清25-羟维生素D[25(OH)D]与身体机能之间的关联。
方法
研究对象为社区居住的297名男性和415名50岁及以上的女性。收集身高（米）和体重（千克）数据。测量血清25(OH)D、甲状旁腺激素、钙和白蛋白水平。血清25(OH)D分为缺乏组：<20 ng/mL，不足组：20 - 30 ng/mL，充足组：≧30 ng/mL。通过握力、从椅子上站起的时间和功能性伸展距离评估身体机能。收集当前吸烟、饮酒、规律运动、任何合并症（高血压、心脏病、糖尿病、肺病和中风）以及疼痛（腰部和膝盖）的信息。
结果
根据血清25(OH)D水平，男性中维生素D缺乏和不足的比例分别为15.2%和56.9%，女性中分别为52.0%和43.6%。在男性中，较高的血清25(OH)D水平与更好的握力（趋势p = 0.003）、从椅子上站起的时间（趋势p = 0.042）和功能性伸展距离（趋势p<0.001）相关。另一方面，在女性中这些参数与血清25(OH)D水平无关。
结论
较高水平的血清25(OH)D与男性较好的身体机能相关，但与女性无关。
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