维生素D的免疫调节作用与呼吸道感染及新冠病毒病的预防
Immunomodulatory Effects of Vitamin D and Prevention of Respiratory Tract Infections and COVID-19.
作者信息
Shoemaker Marni E, Huynh Linda M, Smith Cory M, Mustad Vikkie A, Duarte Maria O, Cramer Joel T
机构信息
College of Health Sciences, The University of Texas at El Paso, El Paso (Drs Shoemaker and Cramer); University of Nebraska Medical Center, Omaha (Ms Huynh); Departments of Kinesiology (Dr Smith) and Public Health Sciences (Dr Duarte), The University of Texas at El Paso, El Paso; and Nutrition Science Consulting, LLC, Galena, Ohio (Dr Mustad).
出版信息
Top Clin Nutr. 2022 Jul-Sep;37(3):203-217. doi: 10.1097/TIN.0000000000000284. Epub 2022 Jun 22.
Little is known about potential protective factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), referred to as COVID-19. Suboptimal vitamin D status is a risk factor for immune dysfunction, respiratory tract infections (RTIs), and viral infections. Supplementation of vitamin D (2000-4000 IU) has decreased incidence and complications from RTIs, respiratory distress syndrome, and pneumonia and may be beneficial in high-risk populations. Given the possible link between low vitamin D status and RTIs, such as COVID-19, this review examined whether vitamin D supplementation can be supported as a nutritional strategy for reducing risk of infection, complications, and mortality from COVID-19 and found that the relationship between vitamin D and RTIs warrants further exploration.
关于严重急性呼吸综合征冠状病毒2（SARS-CoV-2，即新型冠状病毒肺炎）的潜在保护因素，人们所知甚少。维生素D水平欠佳是免疫功能障碍、呼吸道感染（RTIs）和病毒感染的一个风险因素。补充维生素D（2000 - 4000国际单位）可降低呼吸道感染、呼吸窘迫综合征和肺炎的发病率及并发症，对高危人群可能有益。鉴于维生素D水平低与呼吸道感染（如新型冠状病毒肺炎）之间可能存在联系，本综述探讨了补充维生素D是否可作为一种营养策略来降低新型冠状病毒肺炎的感染风险、并发症及死亡率，结果发现维生素D与呼吸道感染之间的关系值得进一步探究。
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